Long‐term follow‐up testing of red cell alloantibodies

Glenn Eugene Ramsey*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

37 Scopus citations

Abstract

Background: In previous studies, 29 to 34 percent of potentially hemolytic red cell antibodies were not detected after short‐term follow‐ up. Study Design and Methods: To examine long‐term detection, records were reviewed for 44 consecutive patients who were tested more than 5 years after their potentially hemolytic red cell antibodies were first identified in this hospital. Results: After 5 to 10 years, 14 (39%) of 36 Rh, Kell, and Duffy system antibodies were not detected on at least one occasion. Twenty‐two other such antibodies were sought again after more than 10 years; 10 (45%) were not detected. When restimulation by pregnancy was excluded, these rates were 42 and 48 percent, respectively. Conclusion: Clinically significant red cell antibody formation is probably more common than previously realized, because nearly half of these antibodies are undetected after long‐term follow‐ up. 1994 AABB

Original languageEnglish (US)
Pages (from-to)122-124
Number of pages3
JournalTransfusion
Volume34
Issue number2
DOIs
StatePublished - Jan 1 1994

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Hematology

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