Looking deeper into vertebrate development

Russell E. Jacobs*, Eric T. Ahrens, Thomas J. Mead, Scott E. Fraser

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

44 Scopus citations


Magnetic resonance imaging (MRI) is a non-invasive imaging method that provides three-dimensional (3-D) images of the internal structure of opaque objects, such as humans and mice. In optimal situations, spatial resolution can approach the micron level. Arbitrarily oriented single-slice images can be obtained in seconds, with full 3-D volume images taking tens of minutes to collect. The exquisite sensitivity of MRI to the local physical and chemical environment provides a wide range of mechanisms giving rise to intrinsic contrast in the MR experiment, thus providing images with dramatic differences between different tissue types (e.g. white vs grey matter, myelinated vs unmyelinated fibres, and brain parenchyma vs ventricles). The recent advent of physiologically sensitive contrast agents opens up a wealth of new avenues of study, even including the in vivo imaging of gene expression.

Original languageEnglish (US)
Pages (from-to)73-76
Number of pages4
JournalTrends in Cell Biology
Issue number2
StatePublished - Feb 1 1999

ASJC Scopus subject areas

  • Cell Biology


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