Loosely coupled mitochondrial oxidative phosphorylation induced by protoporphyrin

David A. Stumpf; Edward R B McCabe; Janice K. Parks; William W. Bullen; Susan Schiff

doi:10.1016/0006-2944(79)90070-X

Loosely coupled mitochondrial oxidative phosphorylation induced by protoporphyrin

David A. Stumpf^*, Edward R B McCabe, Janice K. Parks, William W. Bullen, Susan Schiff

^*Corresponding author for this work

Neurology

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

Protoporphyrin induces loose coupling in rat liver mitochondria at concentrations probably encountered in porphyric patients. Features of porphyric crises suggesting acute mitochondrial dysfunction are reviewed. Porphyrins which accumulate behind enzymatic blocks may produce crises by secondarily altering mitochondrial respiration.

Original language	English (US)
Pages (from-to)	182-189
Number of pages	8
Journal	Biochemical medicine
Volume	21
Issue number	2
DOIs	https://doi.org/10.1016/0006-2944(79)90070-X
State	Published - Apr 1979

Funding

These investigations were supported by a clinical research grant from the Muscular Dystrophy Association, the National Institute of Child Health and Human Development Grant HD 04024, NIH General Research Support Grant RR 05357-15, and NIH Grant RR-69 from the General Clinical Research Centers Program of the Division of Research Resources.

ASJC Scopus subject areas

Biochemistry

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10.1016/0006-2944(79)90070-X

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title = "Loosely coupled mitochondrial oxidative phosphorylation induced by protoporphyrin",

abstract = "Protoporphyrin induces loose coupling in rat liver mitochondria at concentrations probably encountered in porphyric patients. Features of porphyric crises suggesting acute mitochondrial dysfunction are reviewed. Porphyrins which accumulate behind enzymatic blocks may produce crises by secondarily altering mitochondrial respiration.",

author = "Stumpf, {David A.} and McCabe, {Edward R B} and Parks, {Janice K.} and Bullen, {William W.} and Susan Schiff",

note = "Funding Information: These investigations were supported by a clinical research grant from the Muscular Dystrophy Association, the National Institute of Child Health and Human Development Grant HD 04024, NIH General Research Support Grant RR 05357-15, and NIH Grant RR-69 from the General Clinical Research Centers Program of the Division of Research Resources.",

year = "1979",

month = apr,

doi = "10.1016/0006-2944(79)90070-X",

language = "English (US)",

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T1 - Loosely coupled mitochondrial oxidative phosphorylation induced by protoporphyrin

AU - Stumpf, David A.

AU - McCabe, Edward R B

AU - Parks, Janice K.

AU - Bullen, William W.

AU - Schiff, Susan

N1 - Funding Information: These investigations were supported by a clinical research grant from the Muscular Dystrophy Association, the National Institute of Child Health and Human Development Grant HD 04024, NIH General Research Support Grant RR 05357-15, and NIH Grant RR-69 from the General Clinical Research Centers Program of the Division of Research Resources.

PY - 1979/4

Y1 - 1979/4

N2 - Protoporphyrin induces loose coupling in rat liver mitochondria at concentrations probably encountered in porphyric patients. Features of porphyric crises suggesting acute mitochondrial dysfunction are reviewed. Porphyrins which accumulate behind enzymatic blocks may produce crises by secondarily altering mitochondrial respiration.

AB - Protoporphyrin induces loose coupling in rat liver mitochondria at concentrations probably encountered in porphyric patients. Features of porphyric crises suggesting acute mitochondrial dysfunction are reviewed. Porphyrins which accumulate behind enzymatic blocks may produce crises by secondarily altering mitochondrial respiration.

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ER -

Loosely coupled mitochondrial oxidative phosphorylation induced by protoporphyrin

Abstract

Funding

ASJC Scopus subject areas

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