Loosely coupled mitochondrial oxidative phosphorylation induced by protoporphyrin

David A. Stumpf*, Edward R B McCabe, Janice K. Parks, William W. Bullen, Susan Schiff

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


Protoporphyrin induces loose coupling in rat liver mitochondria at concentrations probably encountered in porphyric patients. Features of porphyric crises suggesting acute mitochondrial dysfunction are reviewed. Porphyrins which accumulate behind enzymatic blocks may produce crises by secondarily altering mitochondrial respiration.

Original languageEnglish (US)
Pages (from-to)182-189
Number of pages8
JournalBiochemical medicine
Issue number2
StatePublished - Apr 1979

ASJC Scopus subject areas

  • Biochemistry


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