Loss of expression of transforming growth factor-β receptors is associated with poor prognosis in prostate cancer patients

Isaac Yi Kim, Han Jong Ahn, Sharon Lang, Michael G. Oefelein, Ryoichi Oyasu, James M. Kozlowski, Chung Lee*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

99 Scopus citations

Abstract

Transforming growth factor β (TGF-β) is a potent inhibitor of proliferation in most cells and exerts its effects through an interaction with membrane receptors type I (TGF-βRI) and type II (TGF-βRII). Recently, we have demonstrated a correlation between the loss of expression of TGF- βRI and TGF-βRII and increasing Gleason score in archival human prostate cancer tissues. To evaluate the potential prognostic value of this observation, the present study investigated the expression of TGF-β receptors in association with disease progression after the initial diagnosis in 52 archival human prostate cancer tissues. The expression of both TGF- βRI and TGF-βRII was correlated with the Gleason score, clinical tumor stage, 4-year survival rate, and serological recurrence rate after radical prostatectomy. Results revealed that there was a significant association between the Gleason score and the loss of expression of TGF-βRI (P < 0.025) and TGF-βRII (P < 0.01). However, only the loss of TGF-βRI expression showed a statistically significant association with the clinical tumor stage (P < 0.05), 4-year survival rate (P < 0.05), and serological recurrence rate after radical prostatectomy (P < 0.025). Therefore, these data indicate that the loss of TGF-βRI expression as measured by immunohistochemical staining may be a potential prognostic marker in prostate cancer patients.

Original languageEnglish (US)
Pages (from-to)1625-1630
Number of pages6
JournalClinical Cancer Research
Volume4
Issue number7
StatePublished - Jul 1998

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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