Loss of expression of transforming growth factor β type I and type II receptors correlates with tumor grade in human prostate cancer tissues

Isaac Yi Kim, Han Jong Ahn, David J. Zelner, Jennifer W. Shaw, Sharon Lang, Mitsuyasu Kato, Michael G. Oefelein, Kohei Miyazono, Jeffrey A. Nemeth, James M. Kozlowski, Chung Lee*

*Corresponding author for this work

Research output: Contribution to journalArticle

155 Scopus citations

Abstract

Transforming growth factor β1 (TGF-β1) is a potential regulator of prostate cancer cell growth that signals through a heteromeric complex composed of type I and type II receptors. In the present study, an attempt was made to establish a correlation between expression of TGF-β receptors and tumor grade in archival human prostate cancer tissues. To this end, immunohistochemical studies for TGF-β receptors were carried out on 32 cases of human prostate cancer and 8 samples of benign human prostate. In both benign and malignant human prostate tissues, immunoreactivity for both type I and type II receptors was detected predominantly in epithelial cells. In addition, there was an inverse correlation between the loss of expression of TGF-β1 type I and type II receptors and the tumor grade. Of the 32 prostate cancer cases screened, staining was completely absent in four samples for type II receptor (P < 0.05) and eight samples for type I receptor (P < 0.025). In contrast, all eight samples of benign prostate tissues investigated in this study showed strong staining for both type I and type II receptors. These results, taken together, indicate that human prostate cancer cells frequently have loss of expression of TGF-β type I and/or type II receptors. Furthermore, these observations provide a potential mechanism for prostate cancer cells to escape the growth-inhibitory effect of TGF-β.

Original languageEnglish (US)
Pages (from-to)1255-1261
Number of pages7
JournalClinical Cancer Research
Volume2
Issue number8
StatePublished - Aug 1996

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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    Kim, I. Y., Ahn, H. J., Zelner, D. J., Shaw, J. W., Lang, S., Kato, M., Oefelein, M. G., Miyazono, K., Nemeth, J. A., Kozlowski, J. M., & Lee, C. (1996). Loss of expression of transforming growth factor β type I and type II receptors correlates with tumor grade in human prostate cancer tissues. Clinical Cancer Research, 2(8), 1255-1261.