Loss of genetic information in central nervous system tumors common to children and young adults

C. David James, Ju He, Elisabeth Carlbom, Tom Mikkelsen, Per‐Ake ‐A Ridderheim, Webster K. Cavenee, V. Peter Collins*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

104 Scopus citations

Abstract

The clonal loss of genetic information as revealed by the comparison of normal and tumor DNA restriction fragment length alleles has permitted the determination of the genomic positions of cancer‐recessive mutations. Here we have applied this approach to the analysis of 19 central nervous system tumors that constitute four histologic groups and occur most frequently in children and young adults. The detectable loss of genetic information from cases of medulloblastoma (11 examined) indicates that among such tumors, loss occurs most frequently from the short arm of chromosome 17. For the ependymomas examined (four cases), chromosome 22 was the preferred site for detectable loss. Analysis of pilocytic astrocytomas of the cerebellum (three cases) failed to reveal genetic alterations of any type among such tumors, a finding unique to this histologic group. The single choroid plexus papilloma examined demonstrated loss of genetic information from chromosome 3. Among the 19 tumors, multiple cases of loss were observed from chromosomes 10, 11, 13, and 22, and from the short arm of chromosome 17. Therefore, with regard to the chromosomal locations of implied tumor suppressor genes, these results are consistent with those described for intracranial tumors occurring more commonly in adults of middle to advanced age.

Original languageEnglish (US)
Pages (from-to)94-102
Number of pages9
JournalGenes, Chromosomes and Cancer
Volume2
Issue number2
DOIs
StatePublished - Jan 1 1990

ASJC Scopus subject areas

  • Genetics
  • Cancer Research

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