Loss of heterozygosity in malignant gliomas involves at least three distinct regions on chromosome 10

A. Elisabeth Karlbom*, C. David James, Jürgen Boethius, Webster K. Cavenee, V. Peter Collins, Magnus Nordenskjöld, Catharina Larsson

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

146 Scopus citations

Abstract

A panel of glial tumors consisting of 11 low grade gliomas, 9 anaplastic gliomas, and 29 glioblastomas were analyzed for loss of heterozygosity by examining at least one locus for each chromosome. The frequency of allele loss was highest among the glioblastomas, suggesting that genetic alterations accumulate during glial tumor development. The most common genetic alteration detected involved allele losses of chromosome 10 loci; these losses were observed in all glioblastomas and in three of the anaplastic gliomas. In order to delineate which chromosome 10 region or regions were deleted in association with glial tumor development, a deletion mapping analysis was performed, and this revealed the partial loss of chromosome 10 in eight glioblastomas and two of the anaplastic gliomas. Among these cases, three distinct regions of chromosome 10 were indicated as being targeted for deletion: one telomeric region on 10p and both telomeric and centromeric locations on 10q. These data suggest the existence of multiple chromosome 10 tumor suppressor gene loci whose inactivation is involved in the malignant progression of glioma.

Original languageEnglish (US)
Pages (from-to)169-174
Number of pages6
JournalHuman Genetics
Volume92
Issue number2
DOIs
StatePublished - Sep 1 1993

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

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