Loss of substance P immunoreactivity in the nucleus of the spinal trigeminal tract after intradural tumour compression of the trigeminal nerve

Erik P. Pioro; J. Trevor Hughes; A. Claudio Cuello

doi:10.1016/0304-3940(85)90320-9

Loss of substance P immunoreactivity in the nucleus of the spinal trigeminal tract after intradural tumour compression of the trigeminal nerve

Erik P. Pioro, J. Trevor Hughes, A. Claudio Cuello^*

^*Corresponding author for this work

Neurology

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

The peptide, substance P (SP), is suspected of being a mediator of nociception. Immunoreactive SP is conspicuously present in areas of the mammalian central nervous system which receive nociceptive input. We have observed that compression of the trigeminal nerve by an intradural tumour deposit results in the ipsilateral depletion of SP immunoreactivity in human spinal trigeminal nucleus. These results expand previous experimental animal studies which associate this peptide with a subpopulation of primary sensory neurones and, in addition, demonstrate a correlation between the levels of SP immunoreactivity and premortem clinical sensory alterations.

Original language	English (US)
Pages (from-to)	7-12
Number of pages	6
Journal	Neuroscience Letters
Volume	58
Issue number	1
DOIs	https://doi.org/10.1016/0304-3940(85)90320-9
State	Published - Jul 4 1985

Keywords

human
peptide
spinal trigeminal nucleus
subnucleus interpolaris
subnucleus oralis
substance P immunoreactivity

ASJC Scopus subject areas

General Neuroscience

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10.1016/0304-3940(85)90320-9

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title = "Loss of substance P immunoreactivity in the nucleus of the spinal trigeminal tract after intradural tumour compression of the trigeminal nerve",

abstract = "The peptide, substance P (SP), is suspected of being a mediator of nociception. Immunoreactive SP is conspicuously present in areas of the mammalian central nervous system which receive nociceptive input. We have observed that compression of the trigeminal nerve by an intradural tumour deposit results in the ipsilateral depletion of SP immunoreactivity in human spinal trigeminal nucleus. These results expand previous experimental animal studies which associate this peptide with a subpopulation of primary sensory neurones and, in addition, demonstrate a correlation between the levels of SP immunoreactivity and premortem clinical sensory alterations.",

keywords = "human, peptide, spinal trigeminal nucleus, subnucleus interpolaris, subnucleus oralis, substance P immunoreactivity",

author = "Pioro, {Erik P.} and Hughes, {J. Trevor} and Cuello, {A. Claudio}",

note = "Funding Information: E.P.P. was the recipient of a Rhodes Scholarship. A.C.C. gratefully acknowledges grants from the Wellcome Trust, MRC and the E.P. Abraham Cephalosporin Trust. The technical assistance and expert knowledge of Mr. Ron Beesley is gratefully acknowledged by J.T.H.",

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AU - Pioro, Erik P.

AU - Hughes, J. Trevor

AU - Cuello, A. Claudio

N1 - Funding Information: E.P.P. was the recipient of a Rhodes Scholarship. A.C.C. gratefully acknowledges grants from the Wellcome Trust, MRC and the E.P. Abraham Cephalosporin Trust. The technical assistance and expert knowledge of Mr. Ron Beesley is gratefully acknowledged by J.T.H.

PY - 1985/7/4

Y1 - 1985/7/4

N2 - The peptide, substance P (SP), is suspected of being a mediator of nociception. Immunoreactive SP is conspicuously present in areas of the mammalian central nervous system which receive nociceptive input. We have observed that compression of the trigeminal nerve by an intradural tumour deposit results in the ipsilateral depletion of SP immunoreactivity in human spinal trigeminal nucleus. These results expand previous experimental animal studies which associate this peptide with a subpopulation of primary sensory neurones and, in addition, demonstrate a correlation between the levels of SP immunoreactivity and premortem clinical sensory alterations.

AB - The peptide, substance P (SP), is suspected of being a mediator of nociception. Immunoreactive SP is conspicuously present in areas of the mammalian central nervous system which receive nociceptive input. We have observed that compression of the trigeminal nerve by an intradural tumour deposit results in the ipsilateral depletion of SP immunoreactivity in human spinal trigeminal nucleus. These results expand previous experimental animal studies which associate this peptide with a subpopulation of primary sensory neurones and, in addition, demonstrate a correlation between the levels of SP immunoreactivity and premortem clinical sensory alterations.

KW - human

KW - peptide

KW - spinal trigeminal nucleus

KW - subnucleus interpolaris

KW - subnucleus oralis

KW - substance P immunoreactivity

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Loss of substance P immunoreactivity in the nucleus of the spinal trigeminal tract after intradural tumour compression of the trigeminal nerve

Abstract

Keywords

ASJC Scopus subject areas

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