Lovastatin therapy for hypercholesterolemia in cardiac transplant recipients

Paul C. Kuo, James M. Kirshenbaum, John Gordon, Glenn Laffel, Pia Young, Verdi J. DiSesa, Gilbert H. Mudge*, Douglas E. Vaughan

*Corresponding author for this work

Research output: Contribution to journalArticle

48 Scopus citations

Abstract

Hypercholesterolemia (type II hyperlipidemia) after cardiac transplantation is common and may play a rote in the accelerated rate of coronary atherosclerosis seen following the procedure. However, conventional cholesterol-lowering drugs are either ineffective or contraindicated for use in transplant recipients. The presence of type II hyperlipidemia was identified in 11 cardiac transplant recipients during a mean follow-up period of 15 months (range 3 to 41) after transplantation. Lovastatin, at an initial dosage of 20 mg/day, was administered for a period of 1 year. The maximal dosage of lovastatin was 60 mg/day. All patients received maintenance dosages of immunosuppressive agents, including cyclosporine-A, prednisone and, in some instances, azathioprine. Lipid profiles, hepatic transaminases, serum creatinine, creatine kinase and cyclosporine-A serum trough levels were measured quarterly. Total cholesterol decreased by 27% (354 ± 50 vs 258 ± 36 mg/dl, p < 0.01) after 3 months and remained stable thereafter. Similarly, low density lipoprotein cholesterol decreased by 34% (221 ± 51 vs 146 ± 40 mg/dl, p < 0.01) after 3 months and remained constant. Triglycerides, high density lipoprotein, hepatic transaminases, creatinine, creatine kinase and trough cyclosporine-A levels remained stable during the 1-year follow-up period. Lovastatin was uniformly well tolerated in this study group. When given in modest dosages, lovastatin appears to be a safe, effective and well-tolerated therapy for hypercholesterolemia in cardiac transplant recipients.

Original languageEnglish (US)
Pages (from-to)631-635
Number of pages5
JournalThe American journal of cardiology
Volume64
Issue number10
DOIs
StatePublished - Sep 15 1989

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Fingerprint Dive into the research topics of 'Lovastatin therapy for hypercholesterolemia in cardiac transplant recipients'. Together they form a unique fingerprint.

  • Cite this

    Kuo, P. C., Kirshenbaum, J. M., Gordon, J., Laffel, G., Young, P., DiSesa, V. J., Mudge, G. H., & Vaughan, D. E. (1989). Lovastatin therapy for hypercholesterolemia in cardiac transplant recipients. The American journal of cardiology, 64(10), 631-635. https://doi.org/10.1016/0002-9149(89)90492-X