TY - GEN
T1 - Low-coherence enhanced backscattering and its applications
AU - Backman, V.
AU - Kim, Y.
AU - Liu, Y.
AU - Turzhitsky, V.
AU - Subramanian, H.
AU - Pradhan, P.
AU - Roy, H.
AU - Goldberg, M.
PY - 2007/12/1
Y1 - 2007/12/1
N2 - The phenomenon of enhanced backscattering (EBS) of light, also known as coherent backscattering, has been the object of intensive investigation in non-biological media over the last two decades. However, there have been only a few attempts to explore EBS for tissue characterization and diagnosis. We have recently made progress in the EBS measurements in tissue by taking advantage of low spatial coherence illumination, which has led us to the development of low-coherence enhanced backscattering (LEBS) as a technique to characterize living tissue. In this paper, we review the current state of research on LEBS. In particular, we show that LEBS spectroscopy enables detection of early microarchitectural changes in tissue associated with carcinogenesis prior to the development of histologicallydetectable alterations as well as any other known markers of neoplasia. Thus, LEBS may offer insights into initial events in carcinogenesis.
AB - The phenomenon of enhanced backscattering (EBS) of light, also known as coherent backscattering, has been the object of intensive investigation in non-biological media over the last two decades. However, there have been only a few attempts to explore EBS for tissue characterization and diagnosis. We have recently made progress in the EBS measurements in tissue by taking advantage of low spatial coherence illumination, which has led us to the development of low-coherence enhanced backscattering (LEBS) as a technique to characterize living tissue. In this paper, we review the current state of research on LEBS. In particular, we show that LEBS spectroscopy enables detection of early microarchitectural changes in tissue associated with carcinogenesis prior to the development of histologicallydetectable alterations as well as any other known markers of neoplasia. Thus, LEBS may offer insights into initial events in carcinogenesis.
KW - Cancer
KW - Coherence
KW - Scattering
UR - http://www.scopus.com/inward/record.url?scp=57649146754&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=57649146754&partnerID=8YFLogxK
U2 - 10.1109/IEMBS.2007.4352341
DO - 10.1109/IEMBS.2007.4352341
M3 - Conference contribution
C2 - 18002007
AN - SCOPUS:57649146754
SN - 1424407885
SN - 9781424407880
T3 - Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
SP - 521
EP - 523
BT - 29th Annual International Conference of IEEE-EMBS, Engineering in Medicine and Biology Society, EMBC'07
T2 - 29th Annual International Conference of IEEE-EMBS, Engineering in Medicine and Biology Society, EMBC'07
Y2 - 23 August 2007 through 26 August 2007
ER -
