Low-coherence enhanced backscattering: Review of principles and applications for colon cancer screening

Young L. Kim*, Vladimir M. Turzhitsky, Yang Liu, Hemant K. Roy, Ramesh K. Wali, Hariharan Subramanian, Prabhakar Pradhan, Vadim Backman

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

46 Scopus citations

Abstract

The phenomenon of enhanced backscattering (EBS) of light, also known as coherent backscattering (CBS) of light, has been the object of intensive investigation in nonbiological media over the last two decades. However, there have been only a few attempts to explore EBS for tissue characterization and diagnosis. We have recently made progress in the EBS measurements in tissue by taking advantage of low spatial coherence illumination, which has led us to the development of low-coherence enhanced backscattering (LEBS) spectroscopy. In this work, we review the current state of research on LEBS. After a brief discussion of the basic principle of EBS and LEBS, we present an overview of the unique features of LEBS for tissue characterization, and show that LEBS enables depth-selective spectroscopic assessment of mucosal tissue. Then, we demonstrate the potential of LEBS spectroscopy for predicting the risk of colon carcinogenesis and colonoscopy-free screening for colorectal cancer (CRC).

Original languageEnglish (US)
Article number041125
JournalJournal of Biomedical Optics
Volume11
Issue number4
DOIs
StatePublished - Jul 2006

Keywords

  • Coherent backscattering
  • Colorectal cancer
  • Elastic light scattering
  • Enhanced backscattering
  • Low coherence
  • Spectroscopy

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics
  • Biomedical Engineering
  • Biomaterials

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