Abstract
The phenomenon of enhanced backscattering (EBS) of light, also known as coherent backscattering (CBS) of light, has been the object of intensive investigation in nonbiological media over the last two decades. However, there have been only a few attempts to explore EBS for tissue characterization and diagnosis. We have recently made progress in the EBS measurements in tissue by taking advantage of low spatial coherence illumination, which has led us to the development of low-coherence enhanced backscattering (LEBS) spectroscopy. In this work, we review the current state of research on LEBS. After a brief discussion of the basic principle of EBS and LEBS, we present an overview of the unique features of LEBS for tissue characterization, and show that LEBS enables depth-selective spectroscopic assessment of mucosal tissue. Then, we demonstrate the potential of LEBS spectroscopy for predicting the risk of colon carcinogenesis and colonoscopy-free screening for colorectal cancer (CRC).
| Original language | English (US) |
|---|---|
| Article number | 041125 |
| Journal | Journal of Biomedical Optics |
| Volume | 11 |
| Issue number | 4 |
| DOIs | |
| State | Published - Jul 2006 |
Funding
The study was supported by National Institutes of Health (NIH) grants R01 EB003682 and R01 CA112315, National Science Foundation (NSF) grant BES-0238903, and a grant from The Wallace H. Coulter Foundation. Y.L. Kim was supported in part by a National Cancer Institute training grant R25 CA100600–01A1.
Keywords
- Coherent backscattering
- Colorectal cancer
- Elastic light scattering
- Enhanced backscattering
- Low coherence
- Spectroscopy
ASJC Scopus subject areas
- Electronic, Optical and Magnetic Materials
- Biomaterials
- Atomic and Molecular Physics, and Optics
- Biomedical Engineering
