Low-grade recurrence of a congenital high-grade supratentorial tumor with astrocytic features in the absence of adjuvant therapy

Craig Horbinski*, Donita Dillon, Thomas Pittman

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

The biological behavior of pediatric gliomas and embryonal tumors can be highly variable. A few case reports have described differentiation of primitive neuroectodermal tumors (PNETs) and medulloblastomas, presumably induced by adjuvant chemotherapy and/or radiation. Herein we describe a case of a congenital supratentorial high-grade tumor with astrocytic features that, after near-total surgical resection, was not treated with adjuvant therapies. Thirteen years later the patient presented with recurrent tumor at the original surgical site. The recurrent tumor had completely different morphology compared to the original, with evidence of ganglion cell differentiation and changes more reminiscent of a low-grade pleomorphic xanthoastrocytoma. To the authors' knowledge, this is the first documented case of an untreated high-grade pediatric tumor that spontaneously differentiated into a low grade tumor. The clinical and biological implications of this are briefly discussed.

Original languageEnglish (US)
Pages (from-to)286-291
Number of pages6
JournalNeuropathology
Volume31
Issue number3
DOIs
StatePublished - Jun 1 2011

Keywords

  • Astrocytoma
  • Ganglioglioma
  • Pediatric
  • Pleomorphic xanthoastrocytoma
  • PNET

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Clinical Neurology

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