Low-level SARS-CoV-2 viremia coincident with COVID placentitis and stillbirth

Leena B. Mithal, Sebastian Otero, Lacy M. Simons, Judd F. Hultquist, Emily S. Miller, Egon A. Ozer, Elisheva D. Shanes, Jeffery A. Goldstein*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


SARS-CoV-2 infection in pregnancy and COVID placentitis are associated with an increased risk of stillbirth. We sought to investigate the presence of maternal viremia in people with SARS-CoV-2 infection during pregnancy who had histologic placentitis versus those without placentitis. SARS-CoV-2 qRT-PCR was performed on plasma from 6 patients with COVID placentitis and 12 matched controls without placentitis. SARS-CoV-2 infection occurred between 4/2020–1/2021; the latency between SARS-CoV-2 diagnosis and delivery was 0–76 days. Two placentitis cases demonstrated viremia (1 stillbirth and 1 well infant), while 12/12 controls were negative. Future research may consider viremia as a possible marker of COVID placentitis.

Original languageEnglish (US)
Pages (from-to)79-81
Number of pages3
StatePublished - Apr 2022


  • Placentitis
  • Pregnancy
  • SARS-CoV-2
  • Stillbirth
  • Viremia

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology
  • Developmental Biology


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