@article{835dbffb59c44d7a8b68b81f154e36a8,
title = "Low-level SARS-CoV-2 viremia coincident with COVID placentitis and stillbirth",
abstract = "SARS-CoV-2 infection in pregnancy and COVID placentitis are associated with an increased risk of stillbirth. We sought to investigate the presence of maternal viremia in people with SARS-CoV-2 infection during pregnancy who had histologic placentitis versus those without placentitis. SARS-CoV-2 qRT-PCR was performed on plasma from 6 patients with COVID placentitis and 12 matched controls without placentitis. SARS-CoV-2 infection occurred between 4/2020–1/2021; the latency between SARS-CoV-2 diagnosis and delivery was 0–76 days. Two placentitis cases demonstrated viremia (1 stillbirth and 1 well infant), while 12/12 controls were negative. Future research may consider viremia as a possible marker of COVID placentitis.",
keywords = "COVID, Placentitis, Pregnancy, SARS-CoV-2, Stillbirth, Viremia",
author = "Mithal, {Leena B.} and Sebastian Otero and Simons, {Lacy M.} and Hultquist, {Judd F.} and Miller, {Emily S.} and Ozer, {Egon A.} and Shanes, {Elisheva D.} and Goldstein, {Jeffery A.}",
note = "Funding Information: This work was supported by Friends of Prentice (to J.A.G.), the Stanley Manne Children's Research Institute (to L.B.M.), and from institutional resources supported by the National Center for Advancing Translational Sciences [ UL1TR001422 ]. J.A.G. is supported by the National Institute of Biomedical Imaging and Bioengineering [ K08EB030120 ]. L.B.M. is supported by the National Institute of Allergy and Infectious Diseases [ K23AI139337 ]. Additional funding was provided by the NIH-supported Third Coast CFAR P30 AI117943 (to J.F.H.); NIH grant R21 AI163912 (to J.F.H.); NIH grant U19 AI135964 (to E.A.O.); and through a generous contribution from the Walder Foundation's Chicago Coronavirus Assessment Network (Chicago CAN) Initiative (to J.F.H. & E.A.O.). Funding Information: The authors wish to thank the staff of Northwestern Medicine Prentice Women's Hospital Obstetric COVID Unit, the Northwestern Memorial Hospital Blood Bank, Chemistry Lab, and Pathology Gross Room for making this study possible. We also acknowledge the collaboration of the Northwestern Center for Pathogen Genomics and Microbial Evolution. This research was supported in part through the computational resources and staff contributions provided for the Quest high performance computing facility at Northwestern University , which is jointly supported by the Office of the Provost , the Office for Research , and Northwestern University Information Technology. We also acknowledge Allison Sackowicz, Antonia Willnow, Ashwin Sunderraj, Raveena Aggarwal, Hooman Azad, Chiedza Mupanomunda, and Alexandra Isaia for patient tracking and clinical data collection. Funding Information: This work was supported by Friends of Prentice (to J.A.G.), the Stanley Manne Children's Research Institute (to L.B.M.), and from institutional resources supported by the National Center for Advancing Translational Sciences [UL1TR001422]. J.A.G. is supported by the National Institute of Biomedical Imaging and Bioengineering [K08EB030120]. L.B.M. is supported by the National Institute of Allergy and Infectious Diseases [K23AI139337]. Additional funding was provided by the NIH-supported Third Coast CFAR P30 AI117943 (to J.F.H.); NIH grant R21 AI163912 (to J.F.H.); NIH grant U19 AI135964 (to E.A.O.); and through a generous contribution from the Walder Foundation's Chicago Coronavirus Assessment Network (Chicago CAN) Initiative (to J.F.H. & E.A.O.).The authors wish to thank the staff of Northwestern Medicine Prentice Women's Hospital Obstetric COVID Unit, the Northwestern Memorial Hospital Blood Bank, Chemistry Lab, and Pathology Gross Room for making this study possible. We also acknowledge the collaboration of the Northwestern Center for Pathogen Genomics and Microbial Evolution. This research was supported in part through the computational resources and staff contributions provided for the Quest high performance computing facility at Northwestern University, which is jointly supported by the Office of the Provost, the Office for Research, and Northwestern University Information Technology. We also acknowledge Allison Sackowicz, Antonia Willnow, Ashwin Sunderraj, Raveena Aggarwal, Hooman Azad, Chiedza Mupanomunda, and Alexandra Isaia for patient tracking and clinical data collection. Publisher Copyright: {\textcopyright} 2022 Elsevier Ltd",
year = "2022",
month = apr,
doi = "10.1016/j.placenta.2022.03.003",
language = "English (US)",
volume = "121",
pages = "79--81",
journal = "Placenta",
issn = "0143-4004",
publisher = "W.B. Saunders Ltd",
}