Low-level SARS-CoV-2 viremia coincident with COVID placentitis and stillbirth

Leena B. Mithal; Sebastian Otero; Lacy M. Simons; Judd F. Hultquist; Emily S. Miller; Egon A. Ozer; Elisheva D. Shanes; Jeffery A. Goldstein

doi:10.1016/j.placenta.2022.03.003

Low-level SARS-CoV-2 viremia coincident with COVID placentitis and stillbirth

Leena B. Mithal, Sebastian Otero, Lacy M. Simons, Judd F. Hultquist, Emily S. Miller, Egon A. Ozer, Elisheva D. Shanes, Jeffery A. Goldstein^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

SARS-CoV-2 infection in pregnancy and COVID placentitis are associated with an increased risk of stillbirth. We sought to investigate the presence of maternal viremia in people with SARS-CoV-2 infection during pregnancy who had histologic placentitis versus those without placentitis. SARS-CoV-2 qRT-PCR was performed on plasma from 6 patients with COVID placentitis and 12 matched controls without placentitis. SARS-CoV-2 infection occurred between 4/2020–1/2021; the latency between SARS-CoV-2 diagnosis and delivery was 0–76 days. Two placentitis cases demonstrated viremia (1 stillbirth and 1 well infant), while 12/12 controls were negative. Future research may consider viremia as a possible marker of COVID placentitis.

Original language	English (US)
Pages (from-to)	79-81
Number of pages	3
Journal	Placenta
Volume	121
DOIs	https://doi.org/10.1016/j.placenta.2022.03.003
State	Published - Apr 2022

Keywords

COVID
Placentitis
Pregnancy
SARS-CoV-2
Stillbirth
Viremia

ASJC Scopus subject areas

Obstetrics and Gynecology
Reproductive Medicine
Developmental Biology

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10.1016/j.placenta.2022.03.003

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title = "Low-level SARS-CoV-2 viremia coincident with COVID placentitis and stillbirth",

abstract = "SARS-CoV-2 infection in pregnancy and COVID placentitis are associated with an increased risk of stillbirth. We sought to investigate the presence of maternal viremia in people with SARS-CoV-2 infection during pregnancy who had histologic placentitis versus those without placentitis. SARS-CoV-2 qRT-PCR was performed on plasma from 6 patients with COVID placentitis and 12 matched controls without placentitis. SARS-CoV-2 infection occurred between 4/2020–1/2021; the latency between SARS-CoV-2 diagnosis and delivery was 0–76 days. Two placentitis cases demonstrated viremia (1 stillbirth and 1 well infant), while 12/12 controls were negative. Future research may consider viremia as a possible marker of COVID placentitis.",

keywords = "COVID, Placentitis, Pregnancy, SARS-CoV-2, Stillbirth, Viremia",

author = "Mithal, {Leena B.} and Sebastian Otero and Simons, {Lacy M.} and Hultquist, {Judd F.} and Miller, {Emily S.} and Ozer, {Egon A.} and Shanes, {Elisheva D.} and Goldstein, {Jeffery A.}",

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year = "2022",

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doi = "10.1016/j.placenta.2022.03.003",

language = "English (US)",

volume = "121",

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journal = "Placenta",

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AU - Mithal, Leena B.

AU - Otero, Sebastian

AU - Simons, Lacy M.

AU - Hultquist, Judd F.

AU - Miller, Emily S.

AU - Ozer, Egon A.

AU - Shanes, Elisheva D.

AU - Goldstein, Jeffery A.

PY - 2022/4

Y1 - 2022/4

N2 - SARS-CoV-2 infection in pregnancy and COVID placentitis are associated with an increased risk of stillbirth. We sought to investigate the presence of maternal viremia in people with SARS-CoV-2 infection during pregnancy who had histologic placentitis versus those without placentitis. SARS-CoV-2 qRT-PCR was performed on plasma from 6 patients with COVID placentitis and 12 matched controls without placentitis. SARS-CoV-2 infection occurred between 4/2020–1/2021; the latency between SARS-CoV-2 diagnosis and delivery was 0–76 days. Two placentitis cases demonstrated viremia (1 stillbirth and 1 well infant), while 12/12 controls were negative. Future research may consider viremia as a possible marker of COVID placentitis.

AB - SARS-CoV-2 infection in pregnancy and COVID placentitis are associated with an increased risk of stillbirth. We sought to investigate the presence of maternal viremia in people with SARS-CoV-2 infection during pregnancy who had histologic placentitis versus those without placentitis. SARS-CoV-2 qRT-PCR was performed on plasma from 6 patients with COVID placentitis and 12 matched controls without placentitis. SARS-CoV-2 infection occurred between 4/2020–1/2021; the latency between SARS-CoV-2 diagnosis and delivery was 0–76 days. Two placentitis cases demonstrated viremia (1 stillbirth and 1 well infant), while 12/12 controls were negative. Future research may consider viremia as a possible marker of COVID placentitis.

KW - COVID

KW - Placentitis

KW - Pregnancy

KW - SARS-CoV-2

KW - Stillbirth

KW - Viremia

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AN - SCOPUS:85126082592

SN - 0143-4004

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JO - Placenta

JF - Placenta

ER -

Low-level SARS-CoV-2 viremia coincident with COVID placentitis and stillbirth

Abstract

Keywords

ASJC Scopus subject areas

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