Abstract
Background: Confidence in natural immunity after infection with severe acute respiratory syndrome coronavirus 2 is one reason for vaccine hesitancy. Methods: We measured antibody-mediated neutralization of spike protein-ACE2 receptor binding in a large community-based sample of seropositive individuals who differed in severity of infection (N = 790). Results: A total of 39.8% of infections were asymptomatic, 46.5% were symptomatic with no clinical care, 13.8% were symptomatic with clinical care, and 3.7% required hospitalization. Moderate/high neutralizing activity was present after 41.3% of clinically managed infections, in comparison with 7.9% of symptomatic and 1.9% of asymptomatic infections. Conclusions: Prior coronavirus disease 2019 infection does not guarantee a high level of antibody-mediated protection against reinfection in the general population.
Original language | English (US) |
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Article number | ofac055 |
Journal | Open Forum Infectious Diseases |
Volume | 9 |
Issue number | 3 |
DOIs | |
State | Published - Mar 1 2022 |
Keywords
- COVID-19
- SARS-CoV-2
- Serological testing
- Vaccination
- neutralizing antibodies
ASJC Scopus subject areas
- Clinical Neurology
- Oncology