Low physical function as a risk factor for incident diabetes mellitus and insulin resistance

Allison Longenberger, Jeong Youn Lim, Todd T. Brown, Alison Abraham, Frank Joseph Palella Jr, Rita B. Effros, Trevor Orchard, Maria Mori Brooks, Lawrence A. Kingsley

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Data from 1790 HIV-infected and uninfected men in the Multicenter AIDS Cohort Study (MACS) were analyzed to evaluate relationships between physical function, incident diabetes mellitus (DM) and insulin resistance among HIV-infected and -uninfected men. DM was defined in two ways, using less stringent and more stringent criteria. The 10-item Physical Functioning Scale from the Short Form-36 Health Survey measured baseline physical function. Cumulative DM incidence was highest among HIV-uninfected and HIV-infected men with low physical function. Physical function was a risk factor for DM in HIV-uninfected men and remained so after controlling for BMI, DM family history and race. Among HIV-infected men, physical function was an independent risk factor for DM using the less stringent diabetes definition. This study supports our previous findings that low physical function is an important risk factor for DM in the MACS cohort.

Original languageEnglish (US)
Pages (from-to)439-449
Number of pages11
JournalFuture Virology
Volume6
Issue number4
DOIs
StatePublished - Apr 1 2011

Keywords

  • AIDS
  • HIV
  • diabetes mellitus
  • insulin resistance
  • physical function

ASJC Scopus subject areas

  • Virology

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    Longenberger, A., Lim, J. Y., Brown, T. T., Abraham, A., Palella Jr, F. J., Effros, R. B., Orchard, T., Brooks, M. M., & Kingsley, L. A. (2011). Low physical function as a risk factor for incident diabetes mellitus and insulin resistance. Future Virology, 6(4), 439-449. https://doi.org/10.2217/fvl.11.15