Low rate of rhesus immunization from rh- incompatible blood transfusions during liver and heart transplant surgery

Ramsey Glenn*, F. Hahn Linda, W. Cornell Frank, J. Boczkowski David, Staschak Sandee, Clark Roxann, L. Hardesty Robert, P. Griffith Bartley, E. Starzl Thomas

*Corresponding author for this work

Research output: Contribution to journalArticle

39 Scopus citations

Abstract

Transfusion of one unit or more of Rh-positive red blood cells normally causes circulating anti-D antibody to appear 2-6 months later in 80-95% of Rh persons. We asked whether transplant immunosuppression with cyclosporine and corticosteroids affects Rh immuniza¬tion. Nineteen Rh" liver, heart, and heart-lung transplant recipients received 3—153 (median: 10) units of Rh+ RBCs at surgery and were tested for anti-D >2 months later. Three patients developed anti-D at 11—15 days; one may have had an unusually rapid primary immune response and two were secondary to previous exposure by pregnancy. None of the other 16 patients had anti-D when tested 2.5-51 months later (13 patients, >11.5 months). This low rate of Rhesus immunization in association with cyclosporine immunosuppression allows greater flexibility in meeting the transfusion needs of Rh- liver and heart transplant patients. Caution is still advised in young females and in patients who may have been previously exposed to Rh+ RBCs by transfusion or by pregnancy prior to the availability of perinatal Rh immune globulin twenty years ago. Other humoral immune responses to some vaccines or infectious agents may also be impaired in transplant patients

Original languageEnglish (US)
Pages (from-to)993-995
Number of pages3
JournalTransplantation
Volume47
Issue number6
DOIs
StatePublished - Jun 1989

ASJC Scopus subject areas

  • Transplantation

Fingerprint Dive into the research topics of 'Low rate of rhesus immunization from rh- incompatible blood transfusions during liver and heart transplant surgery'. Together they form a unique fingerprint.

  • Cite this

    Glenn, R., Linda, F. H., Frank, W. C., David, J. B., Sandee, S., Roxann, C., Robert, L. H., Bartley, P. G., & Thomas, E. S. (1989). Low rate of rhesus immunization from rh- incompatible blood transfusions during liver and heart transplant surgery. Transplantation, 47(6), 993-995. https://doi.org/10.1097/00007890-198906000-00015