Low risk of bacteremia in children with febrile seizures

Samir S. Shah*, Elizabeth R. Alpern, Lisa Zwerling, Jennifer R. Reid, Karin L. McGowan, Louis M. Bell

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

33 Scopus citations


Objective: To evaluate the risk of bacteremia in children with febrile seizures treated as outpatients. Methods: A retrospective cohort study was performed involving 379 children aged 2 to 24 months presenting to an urban tertiary care children's hospital emergency department with a febrile seizure between February 1, 1993, and May 31, 1996. Results: The mean patient age was 15.9 months, and 217 (57%) were male. In 40 patients (10.6%), the use of oral antibiotics before initial emergency department evaluation was reported. Bacteremia occurred in 8 (2.1%) of 379 children studied. None of the children with bacteremia had received previous antibiotics. The causative organisms were Streptococcus pneumoniae in 7 cases and group A Streptococcus in 1 case. There were 5 contaminated cultures (1.3%). Although 2 of the 8 children with bacteremia ultimately required admission, there were no serious adverse outcomes. Six of 7 episodes of S pneumoniae bacteremia were caused by serotypes included in the pneumococcal conjugate vaccine, which was not available at the time of this study. Conclusions: Children 2 to 24 months of age with febrile seizures are at similar risk for occult bacteremia as those with fever alone. Widespread use of the pneumococcal conjugate vaccine may further decrease the incidence of bacteremia in this population.

Original languageEnglish (US)
Pages (from-to)469-472
Number of pages4
JournalArchives of Pediatrics and Adolescent Medicine
Issue number5
StatePublished - 2002

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health


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