Lower genital tract infections among HIV-infected and high-risk uninfected women: Findings of the Women's Interagency HIV Study (WIHS)

Ruth M. Greenblatt*, Peter Bacchetti, Susan Barkan, Michael Augenbraun, Sylvia Silver, Robert Delapenha, Patricia Garcia, Usha Mathur, Paolo Miotti, David Burns

*Corresponding author for this work

Research output: Contribution to journalArticle

53 Scopus citations

Abstract

Background and Objectives: Few comparisons of factors associated with sexually transmitted diseases (STDs) and HIV are available for representative samples of American women. Goal of the Study: To compare factors associated with STDs in a large sample of women infected with HIV and women not infected with HIV. Study Design: A cross-sectional analysis of STDs in 2,058 women seropositive (HIV+) for HIV and 567 women seronegative (HIV-) for HIV. Results: HIV+ women were more likely than HIV- women to report previous STDs, with the exceptions of chlamydia and bacterial vaginosis. Both HIV status and CD4 lymphocyte count were associated with evidence of genital ulcerations, warts, and vaginal candidiasis (p <0.001 for all). HIV- women were more apt to report recent vaginal intercourse (p <0.001), a factor that was independently associated with the occurrence of bacterial and protozoan infections. CD4 lymphocyte depletion was the factor most closely associated with the expression of chronic viral infections. Conclusions: In this North American cohort, HIV+ women were more likely than HIV- women to report previous genital tract infections and symptoms. However, the HIV+ women reported less recent sexual activity and few gonococcal or chlamydial infections.

Original languageEnglish (US)
Pages (from-to)143-151
Number of pages9
JournalSexually Transmitted Diseases
Volume26
Issue number3
DOIs
StatePublished - Mar 1999

ASJC Scopus subject areas

  • Dermatology
  • Public Health, Environmental and Occupational Health
  • Microbiology (medical)
  • Infectious Diseases

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    Greenblatt, R. M., Bacchetti, P., Barkan, S., Augenbraun, M., Silver, S., Delapenha, R., Garcia, P., Mathur, U., Miotti, P., & Burns, D. (1999). Lower genital tract infections among HIV-infected and high-risk uninfected women: Findings of the Women's Interagency HIV Study (WIHS). Sexually Transmitted Diseases, 26(3), 143-151. https://doi.org/10.1097/00007435-199903000-00004