TY - JOUR
T1 - Lower morning levels of cortisol and neuropeptides in blood samples from patients with bipolar disorder
AU - Yildiz, Emrah
AU - Elboga, Gulcin
AU - Uygun, Merve Cıkılı
AU - Yilmaz, Rabia
AU - Selvi, Yavuz
AU - Ulusal, Hasan
AU - Çelik, Esra
AU - Sahpolat, Musa
AU - Yildiz, Zeynep Zehra
AU - Hursitoglu, Onur
AU - Altindag, Abdurrahman
AU - Tarakçıoğlu, Mehmet
AU - Pantazopoulos, Harry
N1 - Funding Information:
We would like to thank Gaziantep University Scientific Research Center for financing this project. We are also grateful to all the participants and their families for being included in the research.
Publisher Copyright:
© 2022 The Authors
PY - 2022/12
Y1 - 2022/12
N2 - Background: Several lines of evidence indicate that circadian rhythm disruption is associated with bipolar disorder (BPD). This strong association, along with evidence from genome wide association studies (GWAS) implicating clock and clock controlled genes with BDP and efficacy of lithium treatment, suggests that BPD circadian rhythm disruption may represent a core etiology feature. Lower morning expression of the neuropeptide somatostatin (SST) has been previously reported in the brain and cerebral spinal fluid of subjects with BPD, coinciding with increased morning severity of anxiety and depression. We aimed to test the hypothesis that levels of neuropeptides involved in circadian rhythm regulation, including somatostatin (SST), neuropeptide-Y (NPY), arginine vasopressin (AVP), vasoactive intestinal peptide (VIP) and cortisol levels, are altered in blood samples collected in the morning from patients BPD. Method: Thirty nine patients diagnosed as BPD according to DSM-5, and 38 healthy controls were enrolled in the study. Blood were collected at 9 AM from all subjects. Serum levels of SST, NPY, AVP, VIP and cortisol were measured. Results: We observed significantly lower levels of SST (p = 0.001), NPY (p = 0.001), VIP (p = 0.001) and cortisol levels (p = 0.001) in the morning in subjects with BPD compared to control subjects. Significant positive effects of Young Mania Rating Scale and lithium treatment with cortisol, SST, and VIP levels were observed. Conclusion: Our study suggests that lower morning levels of SST, NPY, VIP and cortisol may represent biomarkers underlying disrupted biological rhythms and behavioral and sleep disturbances observed in patients with BPD.
AB - Background: Several lines of evidence indicate that circadian rhythm disruption is associated with bipolar disorder (BPD). This strong association, along with evidence from genome wide association studies (GWAS) implicating clock and clock controlled genes with BDP and efficacy of lithium treatment, suggests that BPD circadian rhythm disruption may represent a core etiology feature. Lower morning expression of the neuropeptide somatostatin (SST) has been previously reported in the brain and cerebral spinal fluid of subjects with BPD, coinciding with increased morning severity of anxiety and depression. We aimed to test the hypothesis that levels of neuropeptides involved in circadian rhythm regulation, including somatostatin (SST), neuropeptide-Y (NPY), arginine vasopressin (AVP), vasoactive intestinal peptide (VIP) and cortisol levels, are altered in blood samples collected in the morning from patients BPD. Method: Thirty nine patients diagnosed as BPD according to DSM-5, and 38 healthy controls were enrolled in the study. Blood were collected at 9 AM from all subjects. Serum levels of SST, NPY, AVP, VIP and cortisol were measured. Results: We observed significantly lower levels of SST (p = 0.001), NPY (p = 0.001), VIP (p = 0.001) and cortisol levels (p = 0.001) in the morning in subjects with BPD compared to control subjects. Significant positive effects of Young Mania Rating Scale and lithium treatment with cortisol, SST, and VIP levels were observed. Conclusion: Our study suggests that lower morning levels of SST, NPY, VIP and cortisol may represent biomarkers underlying disrupted biological rhythms and behavioral and sleep disturbances observed in patients with BPD.
KW - Anxiety
KW - Anxiety/anxiety disorders
KW - Bipolar disorder
KW - Circadian rhythm
KW - Depression
KW - Neuropeptide
KW - Sleep disorders
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U2 - 10.1016/j.jadr.2022.100406
DO - 10.1016/j.jadr.2022.100406
M3 - Article
AN - SCOPUS:85136476668
SN - 0941-9500
VL - 10
JO - Journal of Affective Disorders Reports
JF - Journal of Affective Disorders Reports
M1 - 100406
ER -
