Lower NK cell numbers in children with untreated juvenile dermatomyositis during the COVID-19 pandemic

Christopher Costin; Gabrielle Morgan; Amer Mohammad Khojah; Marisa Klein-Gitelman; Lauren M. Pachman

doi:10.1016/j.clicom.2023.02.007

Lower NK cell numbers in children with untreated juvenile dermatomyositis during the COVID-19 pandemic

Christopher Costin^*, Gabrielle Morgan, Amer Mohammad Khojah, Marisa Klein-Gitelman, Lauren M. Pachman

^*Corresponding author for this work

Pediatrics

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

RNA viruses have been posited as triggers for Juvenile Dermatomyositis (JDM). The COVID-19 pandemic proved a unique opportunity to observe the effect of a novel RNA virus on JDM incidence and phenotype. We found the incidence of JDM increased from average of 6.9 cases per year from 2012 to 2019 to 9 cases per year from 2020 to 2021. We compared markers of disease activity in the patients diagnosed with JDM prior to and during the pandemic and found that patients diagnosed with JDM during the pandemic had significantly lower average NK cell counts 90.75(± 76) vs 163(±120) (P = 0.038) and NK cell percentage 3.63% (±2.3) vs. 6.6% (±4.1), (P = 0.008). Other markers of JDM did not significantly change. This study suggests that COVID-19 may be a viral trigger for JDM in selected cases and that NK cell dysregulation may be of particular interest in future research of virally triggered JDM.

Original language	English (US)
Pages (from-to)	42-45
Number of pages	4
Journal	Clinical Immunology Communications
Volume	3
DOIs	https://doi.org/10.1016/j.clicom.2023.02.007
State	Published - Dec 2023

Keywords

COVID-19
Juvenile dermatomyositis
NK Cells

ASJC Scopus subject areas

Immunology and Allergy
Immunology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.clicom.2023.02.007

Cite this

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title = "Lower NK cell numbers in children with untreated juvenile dermatomyositis during the COVID-19 pandemic",

abstract = "RNA viruses have been posited as triggers for Juvenile Dermatomyositis (JDM). The COVID-19 pandemic proved a unique opportunity to observe the effect of a novel RNA virus on JDM incidence and phenotype. We found the incidence of JDM increased from average of 6.9 cases per year from 2012 to 2019 to 9 cases per year from 2020 to 2021. We compared markers of disease activity in the patients diagnosed with JDM prior to and during the pandemic and found that patients diagnosed with JDM during the pandemic had significantly lower average NK cell counts 90.75(± 76) vs 163(±120) (P = 0.038) and NK cell percentage 3.63% (±2.3) vs. 6.6% (±4.1), (P = 0.008). Other markers of JDM did not significantly change. This study suggests that COVID-19 may be a viral trigger for JDM in selected cases and that NK cell dysregulation may be of particular interest in future research of virally triggered JDM.",

keywords = "COVID-19, Juvenile dermatomyositis, NK Cells",

author = "Christopher Costin and Gabrielle Morgan and Khojah, {Amer Mohammad} and Marisa Klein-Gitelman and Pachman, {Lauren M.}",

note = "Publisher Copyright: {\textcopyright} 2023",

year = "2023",

month = dec,

doi = "10.1016/j.clicom.2023.02.007",

language = "English (US)",

volume = "3",

pages = "42--45",

journal = "Clinical Immunology Communications",

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T1 - Lower NK cell numbers in children with untreated juvenile dermatomyositis during the COVID-19 pandemic

AU - Costin, Christopher

AU - Morgan, Gabrielle

AU - Khojah, Amer Mohammad

AU - Klein-Gitelman, Marisa

AU - Pachman, Lauren M.

PY - 2023/12

Y1 - 2023/12

N2 - RNA viruses have been posited as triggers for Juvenile Dermatomyositis (JDM). The COVID-19 pandemic proved a unique opportunity to observe the effect of a novel RNA virus on JDM incidence and phenotype. We found the incidence of JDM increased from average of 6.9 cases per year from 2012 to 2019 to 9 cases per year from 2020 to 2021. We compared markers of disease activity in the patients diagnosed with JDM prior to and during the pandemic and found that patients diagnosed with JDM during the pandemic had significantly lower average NK cell counts 90.75(± 76) vs 163(±120) (P = 0.038) and NK cell percentage 3.63% (±2.3) vs. 6.6% (±4.1), (P = 0.008). Other markers of JDM did not significantly change. This study suggests that COVID-19 may be a viral trigger for JDM in selected cases and that NK cell dysregulation may be of particular interest in future research of virally triggered JDM.

AB - RNA viruses have been posited as triggers for Juvenile Dermatomyositis (JDM). The COVID-19 pandemic proved a unique opportunity to observe the effect of a novel RNA virus on JDM incidence and phenotype. We found the incidence of JDM increased from average of 6.9 cases per year from 2012 to 2019 to 9 cases per year from 2020 to 2021. We compared markers of disease activity in the patients diagnosed with JDM prior to and during the pandemic and found that patients diagnosed with JDM during the pandemic had significantly lower average NK cell counts 90.75(± 76) vs 163(±120) (P = 0.038) and NK cell percentage 3.63% (±2.3) vs. 6.6% (±4.1), (P = 0.008). Other markers of JDM did not significantly change. This study suggests that COVID-19 may be a viral trigger for JDM in selected cases and that NK cell dysregulation may be of particular interest in future research of virally triggered JDM.

KW - COVID-19

KW - Juvenile dermatomyositis

KW - NK Cells

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JO - Clinical Immunology Communications

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ER -

Lower NK cell numbers in children with untreated juvenile dermatomyositis during the COVID-19 pandemic

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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