Lower total and regional grey matter brain volumes in youth with perinatally-acquired HIV infection: Associations with HIV disease severity, substance use, and cognition

Pediatric HIV/AIDS Cohort Study (PHACS) and the Pediatric Imaging, Neurocognition, and Genetics (PING) Study

doi:10.1016/j.bbi.2017.01.004

Lower total and regional grey matter brain volumes in youth with perinatally-acquired HIV infection: Associations with HIV disease severity, substance use, and cognition

Pediatric HIV/AIDS Cohort Study (PHACS) and the Pediatric Imaging, Neurocognition, and Genetics (PING) Study

Research output: Contribution to journal › Article › peer-review

32 Scopus citations

Abstract

Despite improved survival due to combination antiretroviral therapy (cART), youth with perinatally-acquired HIV (PHIV) show cognitive deficits and developmental delay at increased rates. HIV affects the brain during critical periods of development, and the brain may be a persistent reservoir for HIV due to suboptimal blood brain barrier penetration of cART. We conducted structural magnetic resonance imaging (sMRI) and cognitive testing in 40 PHIV youth (mean age = 16.7 years) recruited from the NIH Pediatric HIV/AIDS Cohort Study (PHACS) who are part of the first generation of PHIV youth surviving into adulthood. Historical and current HIV disease severity and substance use measures were also collected. Total and regional cortical grey matter brain volumes were compared to a group of 334 typically-developing, HIV-unexposed and uninfected youth (frequency-matched for age and sex) from the Pediatric Imaging, Neurocognition, and Genetics (PING) study (mean age = 16.1 years). PHIV youth had smaller (2.8–5.1%) total and regional grey matter volumes than HIV-unexposed and uninfected youth, with smallest volumes seen among PHIV youth with higher past peak viral load (VL) and recent unsuppressed VL. In PHIV youth, worse cognitive performance correlated with smaller volumes. This pattern of smaller grey matter volumes suggests that PHIV infection may influence brain development and underlie cognitive dysfunction seen in this population. Among PHIV youth, smaller volumes were also linked to substance use (alcohol use: 9.0–13.4%; marijuana use: 10.1–16.0%). In this study, collection of substance use information was limited to the PHIV cohort; future studies should also collect substance use information in controls to further address interactions between HIV and substance use on brain volume.

Original language	English (US)
Pages (from-to)	100-109
Number of pages	10
Journal	Brain, Behavior, and Immunity
Volume	62
DOIs	https://doi.org/10.1016/j.bbi.2017.01.004
State	Published - May 1 2017

Funding

This work was supported by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) with co-funding by the National Institute on Drug Abuse (NIDA), the National Institute of Allergy and Infectious Diseases , the Office of AIDS Research , the National Institute of Mental Health , the National Institute of Neurological Disorders and Stroke , the National Institute on Deafness and Other Communication Disorders , the National Heart, Lung, and Blood Institute , the National Institute of Dental and Craniofacial Research , and the National Institute on Alcohol Abuse and Alcoholism through cooperative agreements with the Harvard T. H. Chan School of Public Health (HD052102) and the Tulane University School of Medicine (HD052104). This work was also supported by NIDA (RC2 DA029475) through the Pediatrics Imaging-Genomics Data Resource (PING) study. C.P.L-dlA. was additionally supported by the Northwestern University Training Program in the Neuroscience of Human Cognition (NIH T32 NS047987), the Northwestern University Medical Scientist Training Program (NIH T32 GM008152), and the Dr. John N. Nicholson Fellowship.

Keywords

Adolescence
Brain
Development
Grey matter
HIV
Magnetic resonance imaging
Neuroimaging
Neuropsychology
Perinatally-acquired

ASJC Scopus subject areas

Immunology
Endocrine and Autonomic Systems
Behavioral Neuroscience

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.bbi.2017.01.004

Cite this

Pediatric HIV/AIDS Cohort Study (PHACS) and the Pediatric Imaging, Neurocognition, and Genetics (PING) Study (2017). Lower total and regional grey matter brain volumes in youth with perinatally-acquired HIV infection: Associations with HIV disease severity, substance use, and cognition. Brain, Behavior, and Immunity, 62, 100-109. https://doi.org/10.1016/j.bbi.2017.01.004

@article{1b4633dfad0e453a9ec4f95976c62cc7,

title = "Lower total and regional grey matter brain volumes in youth with perinatally-acquired HIV infection: Associations with HIV disease severity, substance use, and cognition",

abstract = "Despite improved survival due to combination antiretroviral therapy (cART), youth with perinatally-acquired HIV (PHIV) show cognitive deficits and developmental delay at increased rates. HIV affects the brain during critical periods of development, and the brain may be a persistent reservoir for HIV due to suboptimal blood brain barrier penetration of cART. We conducted structural magnetic resonance imaging (sMRI) and cognitive testing in 40 PHIV youth (mean age = 16.7 years) recruited from the NIH Pediatric HIV/AIDS Cohort Study (PHACS) who are part of the first generation of PHIV youth surviving into adulthood. Historical and current HIV disease severity and substance use measures were also collected. Total and regional cortical grey matter brain volumes were compared to a group of 334 typically-developing, HIV-unexposed and uninfected youth (frequency-matched for age and sex) from the Pediatric Imaging, Neurocognition, and Genetics (PING) study (mean age = 16.1 years). PHIV youth had smaller (2.8–5.1%) total and regional grey matter volumes than HIV-unexposed and uninfected youth, with smallest volumes seen among PHIV youth with higher past peak viral load (VL) and recent unsuppressed VL. In PHIV youth, worse cognitive performance correlated with smaller volumes. This pattern of smaller grey matter volumes suggests that PHIV infection may influence brain development and underlie cognitive dysfunction seen in this population. Among PHIV youth, smaller volumes were also linked to substance use (alcohol use: 9.0–13.4%; marijuana use: 10.1–16.0%). In this study, collection of substance use information was limited to the PHIV cohort; future studies should also collect substance use information in controls to further address interactions between HIV and substance use on brain volume.",

keywords = "Adolescence, Brain, Development, Grey matter, HIV, Magnetic resonance imaging, Neuroimaging, Neuropsychology, Perinatally-acquired",

author = "{Pediatric HIV/AIDS Cohort Study (PHACS) and the Pediatric Imaging, Neurocognition, and Genetics (PING) Study} and {Lewis-de los Angeles}, {C. Paula} and Williams, {Paige L.} and Yanling Huo and Wang, {Shirlene D.} and Uban, {Kristina A.} and Herting, {Megan M.} and Kathleen Malee and Ram Yogev and Csernansky, {John G.} and Sharon Nichols and {Van Dyke}, {Russell B.} and Sowell, {Elizabeth R.} and Lei Wang",

note = "Publisher Copyright: {\textcopyright} 2017 Elsevier Inc.",

year = "2017",

month = may,

day = "1",

doi = "10.1016/j.bbi.2017.01.004",

language = "English (US)",

volume = "62",

pages = "100--109",

journal = "Brain, Behavior, and Immunity",

issn = "0889-1591",

publisher = "Academic Press Inc.",

}

Pediatric HIV/AIDS Cohort Study (PHACS) and the Pediatric Imaging, Neurocognition, and Genetics (PING) Study 2017, 'Lower total and regional grey matter brain volumes in youth with perinatally-acquired HIV infection: Associations with HIV disease severity, substance use, and cognition', Brain, Behavior, and Immunity, vol. 62, pp. 100-109. https://doi.org/10.1016/j.bbi.2017.01.004

Lower total and regional grey matter brain volumes in youth with perinatally-acquired HIV infection: Associations with HIV disease severity, substance use, and cognition. / Pediatric HIV/AIDS Cohort Study (PHACS) and the Pediatric Imaging, Neurocognition, and Genetics (PING) Study.
In: Brain, Behavior, and Immunity, Vol. 62, 01.05.2017, p. 100-109.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Lower total and regional grey matter brain volumes in youth with perinatally-acquired HIV infection

T2 - Associations with HIV disease severity, substance use, and cognition

AU - Pediatric HIV/AIDS Cohort Study (PHACS) and the Pediatric Imaging, Neurocognition, and Genetics (PING) Study

AU - Lewis-de los Angeles, C. Paula

AU - Williams, Paige L.

AU - Huo, Yanling

AU - Wang, Shirlene D.

AU - Uban, Kristina A.

AU - Herting, Megan M.

AU - Malee, Kathleen

AU - Yogev, Ram

AU - Csernansky, John G.

AU - Nichols, Sharon

AU - Van Dyke, Russell B.

AU - Sowell, Elizabeth R.

AU - Wang, Lei

PY - 2017/5/1

Y1 - 2017/5/1

N2 - Despite improved survival due to combination antiretroviral therapy (cART), youth with perinatally-acquired HIV (PHIV) show cognitive deficits and developmental delay at increased rates. HIV affects the brain during critical periods of development, and the brain may be a persistent reservoir for HIV due to suboptimal blood brain barrier penetration of cART. We conducted structural magnetic resonance imaging (sMRI) and cognitive testing in 40 PHIV youth (mean age = 16.7 years) recruited from the NIH Pediatric HIV/AIDS Cohort Study (PHACS) who are part of the first generation of PHIV youth surviving into adulthood. Historical and current HIV disease severity and substance use measures were also collected. Total and regional cortical grey matter brain volumes were compared to a group of 334 typically-developing, HIV-unexposed and uninfected youth (frequency-matched for age and sex) from the Pediatric Imaging, Neurocognition, and Genetics (PING) study (mean age = 16.1 years). PHIV youth had smaller (2.8–5.1%) total and regional grey matter volumes than HIV-unexposed and uninfected youth, with smallest volumes seen among PHIV youth with higher past peak viral load (VL) and recent unsuppressed VL. In PHIV youth, worse cognitive performance correlated with smaller volumes. This pattern of smaller grey matter volumes suggests that PHIV infection may influence brain development and underlie cognitive dysfunction seen in this population. Among PHIV youth, smaller volumes were also linked to substance use (alcohol use: 9.0–13.4%; marijuana use: 10.1–16.0%). In this study, collection of substance use information was limited to the PHIV cohort; future studies should also collect substance use information in controls to further address interactions between HIV and substance use on brain volume.

AB - Despite improved survival due to combination antiretroviral therapy (cART), youth with perinatally-acquired HIV (PHIV) show cognitive deficits and developmental delay at increased rates. HIV affects the brain during critical periods of development, and the brain may be a persistent reservoir for HIV due to suboptimal blood brain barrier penetration of cART. We conducted structural magnetic resonance imaging (sMRI) and cognitive testing in 40 PHIV youth (mean age = 16.7 years) recruited from the NIH Pediatric HIV/AIDS Cohort Study (PHACS) who are part of the first generation of PHIV youth surviving into adulthood. Historical and current HIV disease severity and substance use measures were also collected. Total and regional cortical grey matter brain volumes were compared to a group of 334 typically-developing, HIV-unexposed and uninfected youth (frequency-matched for age and sex) from the Pediatric Imaging, Neurocognition, and Genetics (PING) study (mean age = 16.1 years). PHIV youth had smaller (2.8–5.1%) total and regional grey matter volumes than HIV-unexposed and uninfected youth, with smallest volumes seen among PHIV youth with higher past peak viral load (VL) and recent unsuppressed VL. In PHIV youth, worse cognitive performance correlated with smaller volumes. This pattern of smaller grey matter volumes suggests that PHIV infection may influence brain development and underlie cognitive dysfunction seen in this population. Among PHIV youth, smaller volumes were also linked to substance use (alcohol use: 9.0–13.4%; marijuana use: 10.1–16.0%). In this study, collection of substance use information was limited to the PHIV cohort; future studies should also collect substance use information in controls to further address interactions between HIV and substance use on brain volume.

KW - Adolescence

KW - Brain

KW - Development

KW - Grey matter

KW - HIV

KW - Magnetic resonance imaging

KW - Neuroimaging

KW - Neuropsychology

KW - Perinatally-acquired

UR - http://www.scopus.com/inward/record.url?scp=85010617360&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85010617360&partnerID=8YFLogxK

U2 - 10.1016/j.bbi.2017.01.004

DO - 10.1016/j.bbi.2017.01.004

M3 - Article

C2 - 28089557

AN - SCOPUS:85010617360

SN - 0889-1591

VL - 62

SP - 100

EP - 109

JO - Brain, Behavior, and Immunity

JF - Brain, Behavior, and Immunity

ER -

Lower total and regional grey matter brain volumes in youth with perinatally-acquired HIV infection: Associations with HIV disease severity, substance use, and cognition

Abstract

Funding

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this