LTA4H Prevalence and Mortality in Adult Zambians with Tuberculous Meningitis

Omar K. Siddiqi*, Musie Ghebremichael, Kalo Musukuma, Xin Dang, Eugene Mubanga, Gretchen L. Birbeck, Shawn Love, Clayton Buback, Barry Kosloff, Helen Ayles, Masharip Atadzhanov, Igor J. Koralnik

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

We conducted a prospective cohort study to determine the prevalence of leukotriene A4 hydrolase (LTA4H) polymorphisms in Zambian adults with tuberculous meningitis (TBM) and its association with mortality. We completed genotype testing on 101 definite cases of TBM and 119 consecutive non-TBM controls. The distribution of genotypes among TBM patients was as follows: C/C (0.83), C/T (0.14), T/T (0.03). There was no significant difference in genotype distribution between TBM and non-TBM patients. We found no relationship between LTA4H polymorphism and survival. Prospective studies are needed to determine the benefit of adjuvant steroids in TBM based upon population LTA4H genotype. ANN NEUROL 2021.

Original languageEnglish (US)
JournalAnnals of neurology
DOIs
StateAccepted/In press - 2021

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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