LTA4H Prevalence and Mortality in Adult Zambians with Tuberculous Meningitis

Omar K. Siddiqi; Musie Ghebremichael; Kalo Musukuma; Xin Dang; Eugene Mubanga; Gretchen L. Birbeck; Shawn Love; Clayton Buback; Barry Kosloff; Helen Ayles; Masharip Atadzhanov; Igor J. Koralnik

doi:10.1002/ana.26240

LTA4H Prevalence and Mortality in Adult Zambians with Tuberculous Meningitis

Omar K. Siddiqi^*, Musie Ghebremichael, Kalo Musukuma, Xin Dang, Eugene Mubanga, Gretchen L. Birbeck, Shawn Love, Clayton Buback, Barry Kosloff, Helen Ayles, Masharip Atadzhanov, Igor J. Koralnik

^*Corresponding author for this work

Neurology

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

We conducted a prospective cohort study to determine the prevalence of leukotriene A4 hydrolase (LTA4H) polymorphisms in Zambian adults with tuberculous meningitis (TBM) and its association with mortality. We completed genotype testing on 101 definite cases of TBM and 119 consecutive non-TBM controls. The distribution of genotypes among TBM patients was as follows: C/C (0.83), C/T (0.14), T/T (0.03). There was no significant difference in genotype distribution between TBM and non-TBM patients. We found no relationship between LTA4H polymorphism and survival. Prospective studies are needed to determine the benefit of adjuvant steroids in TBM based upon population LTA4H genotype. ANN NEUROL 2021;90:994–998.

Original language	English (US)
Pages (from-to)	994-998
Number of pages	5
Journal	Annals of neurology
Volume	90
Issue number	6
DOIs	https://doi.org/10.1002/ana.26240
State	Published - Dec 2021

Funding

This work was supported by the NIH (grant numbers NINDS K23NS084054 to O.K.S. and NIAID P30AI 060354 to M.G.).

ASJC Scopus subject areas

Clinical Neurology
Neurology

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title = "LTA4H Prevalence and Mortality in Adult Zambians with Tuberculous Meningitis",

abstract = "We conducted a prospective cohort study to determine the prevalence of leukotriene A4 hydrolase (LTA4H) polymorphisms in Zambian adults with tuberculous meningitis (TBM) and its association with mortality. We completed genotype testing on 101 definite cases of TBM and 119 consecutive non-TBM controls. The distribution of genotypes among TBM patients was as follows: C/C (0.83), C/T (0.14), T/T (0.03). There was no significant difference in genotype distribution between TBM and non-TBM patients. We found no relationship between LTA4H polymorphism and survival. Prospective studies are needed to determine the benefit of adjuvant steroids in TBM based upon population LTA4H genotype. ANN NEUROL 2021;90:994–998.",

author = "Siddiqi, {Omar K.} and Musie Ghebremichael and Kalo Musukuma and Xin Dang and Eugene Mubanga and Birbeck, {Gretchen L.} and Shawn Love and Clayton Buback and Barry Kosloff and Helen Ayles and Masharip Atadzhanov and Koralnik, {Igor J.}",

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year = "2021",

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doi = "10.1002/ana.26240",

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T1 - LTA4H Prevalence and Mortality in Adult Zambians with Tuberculous Meningitis

AU - Siddiqi, Omar K.

AU - Ghebremichael, Musie

AU - Musukuma, Kalo

AU - Dang, Xin

AU - Mubanga, Eugene

AU - Birbeck, Gretchen L.

AU - Love, Shawn

AU - Buback, Clayton

AU - Kosloff, Barry

AU - Ayles, Helen

AU - Atadzhanov, Masharip

AU - Koralnik, Igor J.

PY - 2021/12

Y1 - 2021/12

N2 - We conducted a prospective cohort study to determine the prevalence of leukotriene A4 hydrolase (LTA4H) polymorphisms in Zambian adults with tuberculous meningitis (TBM) and its association with mortality. We completed genotype testing on 101 definite cases of TBM and 119 consecutive non-TBM controls. The distribution of genotypes among TBM patients was as follows: C/C (0.83), C/T (0.14), T/T (0.03). There was no significant difference in genotype distribution between TBM and non-TBM patients. We found no relationship between LTA4H polymorphism and survival. Prospective studies are needed to determine the benefit of adjuvant steroids in TBM based upon population LTA4H genotype. ANN NEUROL 2021;90:994–998.

AB - We conducted a prospective cohort study to determine the prevalence of leukotriene A4 hydrolase (LTA4H) polymorphisms in Zambian adults with tuberculous meningitis (TBM) and its association with mortality. We completed genotype testing on 101 definite cases of TBM and 119 consecutive non-TBM controls. The distribution of genotypes among TBM patients was as follows: C/C (0.83), C/T (0.14), T/T (0.03). There was no significant difference in genotype distribution between TBM and non-TBM patients. We found no relationship between LTA4H polymorphism and survival. Prospective studies are needed to determine the benefit of adjuvant steroids in TBM based upon population LTA4H genotype. ANN NEUROL 2021;90:994–998.

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IS - 6

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LTA4H Prevalence and Mortality in Adult Zambians with Tuberculous Meningitis

Abstract

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