TY - JOUR
T1 - Lung damage and pulmonary uptake of serotonin in intact dogs
AU - Dawson, C. A.
AU - Christensen, C. W.
AU - Rickaby, D. A.
AU - Linehan, J. H.
AU - Johnston, M. R.
PY - 1985
Y1 - 1985
N2 - We examined the influence of glass bead embolization and oleic acid, dextran, and imipramine infusion on the pulmonary uptake of trace doses of [3H]serotonin and extravascular volume accessible to [14C]antipyrine in anesthetized dogs. Embolization and imipramine decreased serotonin uptake by 53 and 61%, respectively, but no change was observed with oleic acid or dextran infusion. The extravascular volume accessible to the antipyrine was reduced by 77% after embolization and increased by 177 and ~44% after oleic acid and dextran infusion, respectively. The results suggest that when the perfused endothelial surface is sufficiently reduced, as with embolization, the uptake of trace doses of serotonin will be depressed. In addition, decreases in serotonin uptake in response to imipramine in this study and in response to certain endothelial toxins in other studies suggest that serotonin uptake can reveal certain kinds of changes in endothelial function. However, the lack of a response to oleic acid-induced damage in the present study suggests that serotonin uptake is not sensitive to all forms of endothelial damage.
AB - We examined the influence of glass bead embolization and oleic acid, dextran, and imipramine infusion on the pulmonary uptake of trace doses of [3H]serotonin and extravascular volume accessible to [14C]antipyrine in anesthetized dogs. Embolization and imipramine decreased serotonin uptake by 53 and 61%, respectively, but no change was observed with oleic acid or dextran infusion. The extravascular volume accessible to the antipyrine was reduced by 77% after embolization and increased by 177 and ~44% after oleic acid and dextran infusion, respectively. The results suggest that when the perfused endothelial surface is sufficiently reduced, as with embolization, the uptake of trace doses of serotonin will be depressed. In addition, decreases in serotonin uptake in response to imipramine in this study and in response to certain endothelial toxins in other studies suggest that serotonin uptake can reveal certain kinds of changes in endothelial function. However, the lack of a response to oleic acid-induced damage in the present study suggests that serotonin uptake is not sensitive to all forms of endothelial damage.
UR - http://www.scopus.com/inward/record.url?scp=0022255474&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0022255474&partnerID=8YFLogxK
U2 - 10.1152/jappl.1985.58.6.1761
DO - 10.1152/jappl.1985.58.6.1761
M3 - Article
C2 - 2409068
AN - SCOPUS:0022255474
SN - 8750-7587
VL - 58
SP - 1761
EP - 1766
JO - Journal of applied physiology
JF - Journal of applied physiology
IS - 6
ER -