Lung Infections and Aging

Jacqueline Marie Kruser*, Keith C. Meyer

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Abstract

Lower respiratory tract infections in the elderly are a significant source of morbidity and mortality. Age-related changes in both systemic and compartmentalized, in lung-specific immune responses show characteristics of both functional decline (immunosenescence) and hyperinflammation (inflamm-aging), which are likely significant risk factors that increase the risk of respiratory tract infections in elderly adults. An improved understanding of aging-associated defects in immune responses that increase susceptibility to respiratory infection as well as mechanisms that prevent excessively exuberant responses to evolving respiratory tract infections that can cause irreversible lung damage is needed. Vaccines that can compensate for or overcome the blunted immune responses in the elderly are needed to maximize the impact of strategies that seek to prevent respiratory infection in the elderly.

Original languageEnglish (US)
Title of host publicationMolecular Aspects of Aging
Subtitle of host publicationUnderstanding Lung Aging
PublisherWiley Blackwell
Pages185-200
Number of pages16
Volume9781118396247
ISBN (Electronic)9781118396292
ISBN (Print)9781118396247
DOIs
StatePublished - Jun 3 2014

Keywords

  • Immune response
  • Immunosenescence
  • Inflamm-aging
  • Lung aging
  • Lung infections
  • Respiratory tract infections

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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