Lung transplantation in scleroderma: Recent advances and lessons

Renea Jablonski, Jane Dematte, Sangeeta Bhorade*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

8 Scopus citations

Abstract

Purpose of reviewThe purpose of this review is to highlight recent data regarding feasibility and outcomes following lung transplantation for patients with systemic sclerosis related pulmonary disease as well as to emphasize areas of uncertainly in need of further study. We include a description of our centre's approach to lung transplant evaluation and posttransplant management in this complex patient population.Recent findingsHistorical data have demonstrated that patients with scleroderma have an increased risk of complications following lung transplantation owing to the multisystem nature of disease, particularly concurrent gastrointestinal, cardiac and renal involvement. Emerging data support the safety of lung transplant in appropriately selected patients with scleroderma-related interstitial lung disease and pulmonary arterial hypertension.SummaryAccumulating evidence validates that a diagnosis of scleroderma is not a priori a contraindication to lung transplant. In the carefully selected patient, both short-term and long-term outcomes following lung transplantation are comparable to counterparts with fibrotic lung disease or pulmonary arterial hypertension. However, further prospective study to detail how these patients should be evaluated and managed posttransplant is definitely needed. Cardiac disease is an emerging cause of morbidity and mortality in the scleroderma population and deserves particular attention during the pre and posttransplant period.

Original languageEnglish (US)
Pages (from-to)562-569
Number of pages8
JournalCurrent opinion in rheumatology
Volume30
Issue number6
DOIs
StatePublished - Nov 1 2018

Keywords

  • lung transplantation
  • outcomes
  • scleroderma

ASJC Scopus subject areas

  • Rheumatology

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