Lungs, microbes and the developing neonate

Barbara B. Warner, Aaron Hamvas

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

Microbes are ubiquitous on the human body and comprise approximately 90% of the cells and 99% of the genes of the human supraorganism. High-throughput sequencing technology has permitted the development of culture-independent means to identify the microbiota that are unique to the various microenvironments of the body and probably contribute some function. Although the respiratory tract interfaces with the environment, the lungs were always thought to be a sterile environment - until recently, when these techniques were applied to healthy and disease states. Further, there appears to be a complex interplay between the development of the gastrointestinal and respiratory microbiota and the regulation of immune function. The contribution of this dynamic metabolic mass to respiratory disease in the newborn is unknown. This article will review emerging data from recent human and murine studies that suggest there is a microbial influence on the development of respiratory disease, but it will also highlight many of the gaps that remain in understanding the function of the respiratory microbiome.

Original languageEnglish (US)
Pages (from-to)337-343
Number of pages7
JournalNeonatology
Volume107
Issue number4
DOIs
StatePublished - Jun 9 2015

Keywords

  • Asthma
  • Bronchopulmonary dysplasia
  • Immune regulation
  • Microbiome
  • Newborn
  • Respiratory disease

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Developmental Biology

Fingerprint Dive into the research topics of 'Lungs, microbes and the developing neonate'. Together they form a unique fingerprint.

  • Cite this