TY - JOUR
T1 - Lupus and cancer
AU - Gayed, M.
AU - Bernatsky, S.
AU - Ramsey-Goldman, R.
AU - Clarke, A. E.
AU - Gordon, Caroline
PY - 2009
Y1 - 2009
N2 - Individuals with systemic lupus erythematosus (SLE) have an increased susceptibility to certain types of cancer. Of particular concern are haematologic malignancies, specifically non-Hodgkin lymphoma, where a three- to four-fold increased risk is seen in SLE, compared with the general population. There is some evidence that immunosuppressive exposures play a role, although there appear to be other factors driving the risk. Lupus disease activity, with resultant dysregulated lymphocyte proliferation, may itself be a mediator of the association between SLE and lymphoma. Aside from haematologic malignancy risk, lung cancer also is increased in SLE compared with the general population, and smoking likely drives this risk in large part. Last but not least, cervical dysplasia is a concern in women with SLE, particularly with exposure to immunosuppressants; routine screening for this complication should not be neglected.
AB - Individuals with systemic lupus erythematosus (SLE) have an increased susceptibility to certain types of cancer. Of particular concern are haematologic malignancies, specifically non-Hodgkin lymphoma, where a three- to four-fold increased risk is seen in SLE, compared with the general population. There is some evidence that immunosuppressive exposures play a role, although there appear to be other factors driving the risk. Lupus disease activity, with resultant dysregulated lymphocyte proliferation, may itself be a mediator of the association between SLE and lymphoma. Aside from haematologic malignancy risk, lung cancer also is increased in SLE compared with the general population, and smoking likely drives this risk in large part. Last but not least, cervical dysplasia is a concern in women with SLE, particularly with exposure to immunosuppressants; routine screening for this complication should not be neglected.
KW - Cancer
KW - Malignancy
KW - Non-Hodgkin lymphoma
KW - Systemic lupus erythematosus
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U2 - 10.1177/0961203309102556
DO - 10.1177/0961203309102556
M3 - Review article
C2 - 19395448
AN - SCOPUS:65149101308
VL - 18
SP - 479
EP - 485
JO - Lupus
JF - Lupus
SN - 0961-2033
IS - 6
ER -