Lymph Node Staging and Treatment in Pediatric Patients With Soft Tissue Sarcomas: A Consensus Opinion From the Children's Oncology Group, European paediatric Soft Tissue Sarcoma Study Group, and the Cooperative Weichteilsarkom Studiengruppe

Sheila Terwisscha van Scheltinga; Reineke A. Schoot; Jonathan C. Routh; Guido Seitz; Simon C. Kao; Bart de Keizer; Barry Shulkin; Roelof van Ewijk; Beth McCarville; Dana Casey; Wendy Allen-Rhoades; Federico Mercolini; Hans Merks; Daniel Orbach; Tejas Kapadia; David O. Walterhouse; Raquel Davila Fajardo; Laura Hiemcke-Jiwa; Christiane Franzius; Federica De Corti; Vivian Tang; Jonathan Metts; Saphna Oberoi; Christian Vokuhl; Roshni Dasgupta; Suzi Birz; David Rodeberg

doi:10.1002/pbc.31538

Lymph Node Staging and Treatment in Pediatric Patients With Soft Tissue Sarcomas: A Consensus Opinion From the Children's Oncology Group, European paediatric Soft Tissue Sarcoma Study Group, and the Cooperative Weichteilsarkom Studiengruppe

Sheila Terwisscha van Scheltinga^*, Reineke A. Schoot, Jonathan C. Routh, Guido Seitz, Simon C. Kao, Bart de Keizer, Barry Shulkin, Roelof van Ewijk, Beth McCarville, Dana Casey, Wendy Allen-Rhoades, Federico Mercolini, Hans Merks, Daniel Orbach, Tejas Kapadia, David O. Walterhouse, Raquel Davila Fajardo, Laura Hiemcke-Jiwa, Christiane Franzius, Federica De CortiVivian Tang, Jonathan Metts, Saphna Oberoi, Christian Vokuhl, Roshni Dasgupta, Suzi Birz, David Rodeberg

^*Corresponding author for this work

Pediatrics

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Accurate staging of nodal involvement in pediatric sarcoma patients is important to determine correct systemic and local therapy, with the goal to reduce subsequent recurrences. However, differences in lymph node staging strategies, definitions, and treatment protocols between the Children's Oncology Group (COG), European paediatric Soft tissue sarcoma Study Group (EpSSG), and the Cooperative Weichteilsarkom Studiengruppe (CWS) complicate comparisons. In this article, we aim to establish internationally recognized recommendations for lymph node assessment and treatment of children and adolescents diagnosed with rhabdomyosarcoma (RMS) and non-rhabdomyosarcoma soft tissue sarcoma (NRSTS) according to the Consensus Conference Standard Operating Procedure methodology.

Original language	English (US)
Article number	e31538
Journal	Pediatric Blood and Cancer
Volume	72
Issue number	4
DOIs	https://doi.org/10.1002/pbc.31538
State	Published - Apr 2025

Funding

The International Soft Tissue Sarcoma Consortium and the Pediatric Cancer Data Commons are supported in part by Cancer Research Foundation, Children's Research Foundation, Comer Development Board, KickCancer, King Baudouin Foundation, Rally Foundation for Childhood Cancer Research, Seattle Children's Foundation from Kat's Crew Guild through the Sarcoma Research Fund, St. Baldrick's Foundation, The Andrew McDonough B+ Foundation, Maddie's Promise, Summer's Way Foundation, Friends of T.J. Foundation, Sebastian Strong, and the Sarah Jane Adicoff Endowment for Research in Rhabdomyosarcoma through the Seattle Children's Foundation. This work is made possible through the efforts of Children's Oncology Group, Cooperative Weichteilsarkom Studiengruppe der GPOH (CWS), the European Soft tissue sarcoma Study Group, MMT Malignant Mesenchymal Tumour Committee, and STSC AIEOP Italian Soft Tissue Sarcoma Committee. paediatric

Keywords

including soft tissue
non-rhabdoid
pediatric oncology
rhabdomyosarcoma
sarcomas

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Hematology
Oncology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Terwisscha van Scheltinga, S., Schoot, R. A., Routh, J. C., Seitz, G., Kao, S. C., de Keizer, B., Shulkin, B., Ewijk, R. V., McCarville, B., Casey, D., Allen-Rhoades, W., Mercolini, F., Merks, H., Orbach, D., Kapadia, T., Walterhouse, D. O., Davila Fajardo, R., Hiemcke-Jiwa, L., Franzius, C., ... Rodeberg, D. (2025). Lymph Node Staging and Treatment in Pediatric Patients With Soft Tissue Sarcomas: A Consensus Opinion From the Children's Oncology Group, European paediatric Soft Tissue Sarcoma Study Group, and the Cooperative Weichteilsarkom Studiengruppe. Pediatric Blood and Cancer, 72(4), Article e31538. https://doi.org/10.1002/pbc.31538

Terwisscha van Scheltinga, Sheila ; Schoot, Reineke A. ; Routh, Jonathan C. et al. / Lymph Node Staging and Treatment in Pediatric Patients With Soft Tissue Sarcomas : A Consensus Opinion From the Children's Oncology Group, European paediatric Soft Tissue Sarcoma Study Group, and the Cooperative Weichteilsarkom Studiengruppe. In: Pediatric Blood and Cancer. 2025 ; Vol. 72, No. 4.

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title = "Lymph Node Staging and Treatment in Pediatric Patients With Soft Tissue Sarcomas: A Consensus Opinion From the Children's Oncology Group, European paediatric Soft Tissue Sarcoma Study Group, and the Cooperative Weichteilsarkom Studiengruppe",

abstract = "Accurate staging of nodal involvement in pediatric sarcoma patients is important to determine correct systemic and local therapy, with the goal to reduce subsequent recurrences. However, differences in lymph node staging strategies, definitions, and treatment protocols between the Children's Oncology Group (COG), European paediatric Soft tissue sarcoma Study Group (EpSSG), and the Cooperative Weichteilsarkom Studiengruppe (CWS) complicate comparisons. In this article, we aim to establish internationally recognized recommendations for lymph node assessment and treatment of children and adolescents diagnosed with rhabdomyosarcoma (RMS) and non-rhabdomyosarcoma soft tissue sarcoma (NRSTS) according to the Consensus Conference Standard Operating Procedure methodology.",

keywords = "including soft tissue, non-rhabdoid, pediatric oncology, rhabdomyosarcoma, sarcomas",

author = "\{Terwisscha van Scheltinga\}, Sheila and Schoot, \{Reineke A.\} and Routh, \{Jonathan C.\} and Guido Seitz and Kao, \{Simon C.\} and \{de Keizer\}, Bart and Barry Shulkin and Ewijk, \{Roelof van\} and Beth McCarville and Dana Casey and Wendy Allen-Rhoades and Federico Mercolini and Hans Merks and Daniel Orbach and Tejas Kapadia and Walterhouse, \{David O.\} and \{Davila Fajardo\}, Raquel and Laura Hiemcke-Jiwa and Christiane Franzius and \{De Corti\}, Federica and Vivian Tang and Jonathan Metts and Saphna Oberoi and Christian Vokuhl and Roshni Dasgupta and Suzi Birz and David Rodeberg",

note = "Publisher Copyright: {\textcopyright} 2025 Wiley Periodicals LLC.",

year = "2025",

month = apr,

doi = "10.1002/pbc.31538",

language = "English (US)",

volume = "72",

journal = "Pediatric Blood and Cancer",

issn = "1545-5009",

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Terwisscha van Scheltinga, S, Schoot, RA, Routh, JC, Seitz, G, Kao, SC, de Keizer, B, Shulkin, B, Ewijk, RV, McCarville, B, Casey, D, Allen-Rhoades, W, Mercolini, F, Merks, H, Orbach, D, Kapadia, T, Walterhouse, DO, Davila Fajardo, R, Hiemcke-Jiwa, L, Franzius, C, De Corti, F, Tang, V, Metts, J, Oberoi, S, Vokuhl, C, Dasgupta, R, Birz, S & Rodeberg, D 2025, 'Lymph Node Staging and Treatment in Pediatric Patients With Soft Tissue Sarcomas: A Consensus Opinion From the Children's Oncology Group, European paediatric Soft Tissue Sarcoma Study Group, and the Cooperative Weichteilsarkom Studiengruppe', Pediatric Blood and Cancer, vol. 72, no. 4, e31538. https://doi.org/10.1002/pbc.31538

Lymph Node Staging and Treatment in Pediatric Patients With Soft Tissue Sarcomas: A Consensus Opinion From the Children's Oncology Group, European paediatric Soft Tissue Sarcoma Study Group, and the Cooperative Weichteilsarkom Studiengruppe. / Terwisscha van Scheltinga, Sheila; Schoot, Reineke A.; Routh, Jonathan C. et al.
In: Pediatric Blood and Cancer, Vol. 72, No. 4, e31538, 04.2025.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Lymph Node Staging and Treatment in Pediatric Patients With Soft Tissue Sarcomas

T2 - A Consensus Opinion From the Children's Oncology Group, European paediatric Soft Tissue Sarcoma Study Group, and the Cooperative Weichteilsarkom Studiengruppe

AU - Terwisscha van Scheltinga, Sheila

AU - Schoot, Reineke A.

AU - Routh, Jonathan C.

AU - Seitz, Guido

AU - Kao, Simon C.

AU - de Keizer, Bart

AU - Shulkin, Barry

AU - Ewijk, Roelof van

AU - McCarville, Beth

AU - Casey, Dana

AU - Allen-Rhoades, Wendy

AU - Mercolini, Federico

AU - Merks, Hans

AU - Orbach, Daniel

AU - Kapadia, Tejas

AU - Walterhouse, David O.

AU - Davila Fajardo, Raquel

AU - Hiemcke-Jiwa, Laura

AU - Franzius, Christiane

AU - De Corti, Federica

AU - Tang, Vivian

AU - Metts, Jonathan

AU - Oberoi, Saphna

AU - Vokuhl, Christian

AU - Dasgupta, Roshni

AU - Birz, Suzi

AU - Rodeberg, David

PY - 2025/4

Y1 - 2025/4

N2 - Accurate staging of nodal involvement in pediatric sarcoma patients is important to determine correct systemic and local therapy, with the goal to reduce subsequent recurrences. However, differences in lymph node staging strategies, definitions, and treatment protocols between the Children's Oncology Group (COG), European paediatric Soft tissue sarcoma Study Group (EpSSG), and the Cooperative Weichteilsarkom Studiengruppe (CWS) complicate comparisons. In this article, we aim to establish internationally recognized recommendations for lymph node assessment and treatment of children and adolescents diagnosed with rhabdomyosarcoma (RMS) and non-rhabdomyosarcoma soft tissue sarcoma (NRSTS) according to the Consensus Conference Standard Operating Procedure methodology.

AB - Accurate staging of nodal involvement in pediatric sarcoma patients is important to determine correct systemic and local therapy, with the goal to reduce subsequent recurrences. However, differences in lymph node staging strategies, definitions, and treatment protocols between the Children's Oncology Group (COG), European paediatric Soft tissue sarcoma Study Group (EpSSG), and the Cooperative Weichteilsarkom Studiengruppe (CWS) complicate comparisons. In this article, we aim to establish internationally recognized recommendations for lymph node assessment and treatment of children and adolescents diagnosed with rhabdomyosarcoma (RMS) and non-rhabdomyosarcoma soft tissue sarcoma (NRSTS) according to the Consensus Conference Standard Operating Procedure methodology.

KW - including soft tissue

KW - non-rhabdoid

KW - pediatric oncology

KW - rhabdomyosarcoma

KW - sarcomas

UR - https://www.scopus.com/pages/publications/85215670590

UR - https://www.scopus.com/inward/citedby.url?scp=85215670590&partnerID=8YFLogxK

U2 - 10.1002/pbc.31538

DO - 10.1002/pbc.31538

M3 - Article

C2 - 39844722

AN - SCOPUS:85215670590

SN - 1545-5009

VL - 72

JO - Pediatric Blood and Cancer

JF - Pediatric Blood and Cancer

IS - 4

M1 - e31538

ER -

Terwisscha van Scheltinga S, Schoot RA, Routh JC, Seitz G, Kao SC, de Keizer B et al. Lymph Node Staging and Treatment in Pediatric Patients With Soft Tissue Sarcomas: A Consensus Opinion From the Children's Oncology Group, European paediatric Soft Tissue Sarcoma Study Group, and the Cooperative Weichteilsarkom Studiengruppe. Pediatric Blood and Cancer. 2025 Apr;72(4):e31538. doi: 10.1002/pbc.31538

Lymph Node Staging and Treatment in Pediatric Patients With Soft Tissue Sarcomas: A Consensus Opinion From the Children's Oncology Group, European paediatric Soft Tissue Sarcoma Study Group, and the Cooperative Weichteilsarkom Studiengruppe

Abstract

Funding

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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