Lymphatic endothelial cell plasticity in development and disease

Wanshu Ma, Guillermo Oliver

Research output: Contribution to journalReview articlepeer-review

28 Scopus citations


The lymphatic vasculature is crucial for maintaining tissue-fluid homeostasis, providing immune surveillance and mediating lipid absorption. The lymphatic vasculature is tightly associated with the blood vasculature, although it exhibits distinct morphological and functional features. Endothelial cells (ECs) lineage fate specification is determined during embryonic development; however, accumulating evidence suggests that differentiated ECs exhibit remarkable heterogeneity and plasticity. In this review, we provide an overview of the molecular mechanisms promoting lymphatic cell fate specification in the mammalian embryo. We also summarize available data suggesting that lymphatic EC fate is reprogrammable in normal and pathological settings. We further discuss the possible advantages of cell fate manipulation to treat certain disorders associated with lymphatic dysfunction.

Original languageEnglish (US)
Article numberA007
Pages (from-to)444-452
Number of pages9
Issue number6
StatePublished - Oct 11 2017

ASJC Scopus subject areas

  • Physiology


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