Abstract
In this study we investigated the pattern of T lymphocyte changes in 16 adult patients with acute myeloid leukaemia (8), non-Hodgkin's lymphoma (4) and Hodgkin's disease (4) treated with continuous infusion of recombinant interleukin-2 (rIL-2). Effects indicative of lymphocyte activation occurred even prior to any rIL-2 therapy in these patients, being most prominent in patients with active diseases. Following each course of cytokine therapy, there were further changes in these parameters. Significant rebound lymphocytoses occurred with a concomitant increase in the cytotoxic functions and induction of the cytotoxicity-linked cytoplasmic serine esterase. Hence, both the natural killer and lectin-dependent cellular cytotoxicity activities were up-regulated. There were also increases in the serum sIL-2 receptor, sCD4 and sCD8 levels. More CD3+ lymphocytes, especially cells bearing CD4, were also recruited to the pool of potential effector cells, as demonstrated by the greater proportion of cells expressing the cytoplasmic serine esterase.
Original language | English (US) |
---|---|
Pages (from-to) | 133-137 |
Number of pages | 5 |
Journal | Cancer Immunology Immunotherapy |
Volume | 33 |
Issue number | 2 |
DOIs | |
State | Published - Mar 1991 |
Keywords
- Leukaemias
- Lymphocyte activation
- Lymphomas
- Recombinant IL-2
- Serine esterase
ASJC Scopus subject areas
- Oncology
- Cancer Research
- Immunology and Allergy
- Immunology