Lymphocytes and lymphokines in aplastic anemia: Pathogenic role and implications for pathogenesis

N. S. Young, E. Leonard, L. Platanias

Research output: Contribution to journalReview articlepeer-review

18 Scopus citations

Abstract

Clinical observations first suggested an immune basis for aplastic anemia. Laboratory studies have implicated a suppressor T lymphocyte producing molecules like γ-interferon that inhibit hematopoiesis. Extrapolation from in vitro studies is complicated by synergy and antagonism among lymphokines and interleukins, the presence of regulators of proliferation produced by bone marrow cells, and possible differences between endogenous and exogenously administered molecules on cell growth.

Original languageEnglish (US)
Pages (from-to)87-100
Number of pages14
JournalBlood Cells
Volume13
Issue number1-2
StatePublished - Jan 1 1987

ASJC Scopus subject areas

  • Hematology

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