TY - JOUR
T1 - Lymphocytic Choriomeningitis Virus Clone 13 Infection Results in CD8 T Cell-Mediated Host Mortality in Diacylglycerol Kinase α-Deficient Mice
AU - Kudek, Matthew R.
AU - Xin, Gang
AU - Alson, Donia
AU - Holzhauer, Sandra
AU - Shen, Jian
AU - Kasmani, Moujtaba Y.
AU - Riese, Matthew
AU - Cui, Weiguo
N1 - Funding Information:
This work was supported by the St. Baldrick’s Foundation Fellowship (812679 to M.R.K.). M.Y.K. is a member of the Medical Scientist Training Program at the Medical College of Wisconsin, which is partially supported by a training grant from National Institute of General Medical Sciences, National Institutes of Health (T32-GM080202). W.C. was supported by National Institute of Allergy and Infectious Diseases, National Institutes of Health Grants AI125741 and AI148403, by an American Cancer Society Research Scholar Grant, and by an Advancing a Healthier Wisconsin Endowment Grant.
Publisher Copyright:
Copyright © 2023 by The American Association of Immunologists, Inc.
PY - 2023/5/1
Y1 - 2023/5/1
N2 - Diacylglycerol is a potent element of intracellular secondary signaling cascades whose production is enhanced by cell-surface receptor agonism and function is regulated by enzymatic degradation by diacylglycerol kinases (DGKs). In T cells, stringent regulation of the activity of this second messenger maintains an appropriate balance between effector function and anergy. In this article, we demonstrate that DGKα is an indispensable regulator of TCR-mediated activation of CD8 T cells in lymphocytic choriomeningitis virus Clone 13 viral infection. In the absence of DGKα, Clone 13 infection in a murine model results in a pathologic, proinflammatory state and a multicellular immunopathologic host death that is predominantly driven by CD8 effector T cells.
AB - Diacylglycerol is a potent element of intracellular secondary signaling cascades whose production is enhanced by cell-surface receptor agonism and function is regulated by enzymatic degradation by diacylglycerol kinases (DGKs). In T cells, stringent regulation of the activity of this second messenger maintains an appropriate balance between effector function and anergy. In this article, we demonstrate that DGKα is an indispensable regulator of TCR-mediated activation of CD8 T cells in lymphocytic choriomeningitis virus Clone 13 viral infection. In the absence of DGKα, Clone 13 infection in a murine model results in a pathologic, proinflammatory state and a multicellular immunopathologic host death that is predominantly driven by CD8 effector T cells.
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U2 - 10.4049/jimmunol.2101011
DO - 10.4049/jimmunol.2101011
M3 - Article
C2 - 36920384
AN - SCOPUS:85152632053
SN - 0022-1767
VL - 210
SP - 1281
EP - 1291
JO - Journal of Immunology
JF - Journal of Immunology
IS - 9
ER -