Lymphokine modulation of fibroblast proliferation

E. Neilson, S. M. Phillips, S. Jimenez

Research output: Contribution to journalArticlepeer-review

50 Scopus citations


In an experimental model of interstitial nephritis resulting in fibrosis, lymphokines secreted by a common population of antigen-reactive T lymphocytes have been shown to exert a bidirectional influence on fibroblast proliferation and collagen synthesis. We report that these lymphokines can be chromatographically separated into two fractions. The larger m.w. fraction stimulated fibroblast proliferation whereas the smaller m.w. fraction was inhibitory. These results further clarify potentially important immune regulators of fibrogenesis.

Original languageEnglish (US)
Pages (from-to)1484-1486
Number of pages3
JournalJournal of Immunology
Issue number3
StatePublished - Jan 1 1982

ASJC Scopus subject areas

  • Immunology


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