Lymphoma with autoimmune neutropenia and hepatic sinusoidal infiltration: A syndrome

M. S. Kruskall, S. A. Weitzman, T. P. Stossel, N. Harris, S. H. Robinson

Research output: Contribution to journalArticlepeer-review

26 Scopus citations

Abstract

A relation between lymphoma and autoimmune neutropenia, unlike autoimmune hemolytic anemia and idiopathic thrombocytopenic purpura, has not previously been well documented. We report a patient with a disorder presenting as autoimmune agranulocytosis, splenomegaly, and infiltration of the hepatic sinusoids by lymphocytes. Antineutrophil antibodies were present. Over a 2 1/2 -year period, the illness progressed to an aggressive, poorly differentiated lymphocytic lymphoma with terminal liver failure and fibrosis. Peripheral blood lymphocyte markers identified the tumor as a proliferation of T-cells of the helper class. A review of previous literature disclosed other reports of similar patients who had neutropenia, a lymphoproliferative illness, and hepatic disease. Our case is representative of a previously unrecognized syndrome characterized by autoimmune neutropenia in the setting of a lymphoproliferative disorder of T cells, with a predilection for liver involvement.

Original languageEnglish (US)
Pages (from-to)202-205
Number of pages4
JournalUnknown Journal
Volume97
Issue number2
DOIs
StatePublished - Jan 1 1982

ASJC Scopus subject areas

  • Internal Medicine

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