Lysergic acid diethylamide: Evidence for stimulation of pituitary dopamine receptors

Herbert Y. Meltzer*, Richard G. Fessler, Miljana Simonovic, John Doherty, Victor S. Fang

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

Lysergic acid diethylamide (LSD), 0.05 mg/kg and 0.20 mg/kg, significantly decreased plasma prolactin (PRL) levels in male rats. LSD, 0.20 mg/kg, also inhibits the increase in plasma PRL levels produced by chlorpromazine (CPZ), 5 mg/kg, and alpha-methylparatyrosine (AMPT), 50 mg/kg, both of which interfere with dopaminergic inhibition of PRL secretion. LSD was more potent than methysergide, a serotonin receptor blocker, in lowering plasma PRL levels and more potent than apomorphine, a known direct acting dopamine agonist, in blocking the increase in plasma PRL produced by quipazine, a 5-HT agonist. These results suggest LSD has potent dopamine agonist properties on the rat pituitary or hypothalamic dopamine receptors which directly or indirectly inhibit PRL secretion.

Original languageEnglish (US)
Pages (from-to)39-44
Number of pages6
JournalPsychopharmacology
Volume54
Issue number1
DOIs
StatePublished - Jan 1977

Keywords

  • Alpha-methylparatyrosine
  • Apomorphine
  • Chlorpromazine
  • Dopamine
  • LSD
  • Methysergide
  • Prolactin
  • Quipazine
  • Serotonin

ASJC Scopus subject areas

  • Pharmacology

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