Lysergic acid diethylamide: evidence for stimulation of pituitary dopamine receptors

H. Y. Meltzer, R. G. Fessler, M. Simonovic, J. Doherty, V. S. Fang

Research output: Contribution to journalArticlepeer-review


Lysergic acid diethylamide (LSD), 0.05 mg/kg and 0.20 mg/kg, significantly decreased plasma prolactin (PRL) levels in male rats. LSD, 0.20 mg/kg, also inhibits the increase in plasma PRL levels produced by chlorpromazine (CPZ), 5 mg/kg, and alpha-methyl-paratyrosine (AMPT), 50 mg/kg, both of which interfere with dopaminergic inhibition of PRL secretion. LSD was more potent than methysergide, a serotonin receptor blocker, in lowering plasma PRL levels and more potent than apomorphine, a known direct acting dopamine agonist, in blocking the increase in plasma PRL produced by quipazine, a 5-HT agonist. These results suggest LSD has potent dopamine agonist properties on the rat pituitary or hypothalamic dopamine receptors which directly or indirectly inhibit PRL secretion.

Original languageEnglish (US)
Pages (from-to)39-44
Number of pages6
JournalUnknown Journal
Issue number1
StatePublished - Jan 1 1977

ASJC Scopus subject areas

  • Pharmacology


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