Ménage à trois: Sustained therapeutic anti-tumor immunity requires multiple partners in malignant glioma

Derek A. Wainwright; Maciej S. Lesniak

doi:10.4161/onci.28927

Ménage à trois: Sustained therapeutic anti-tumor immunity requires multiple partners in malignant glioma

Derek A. Wainwright, Maciej S. Lesniak^*

^*Corresponding author for this work

Neurological Surgery

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Glioblastoma is an aggressive primary brain cancer. Given our interest in novel immunotherapies, we have recently shown that inhibiting CTLA-4, PD-L1 and IDO results in a dramatic survival advantage in mice with brain tumors. Our preclinical study supports the rapid translation of this approach into phase I clinical trial.

Original language	English (US)
Article number	e28927
Journal	OncoImmunology
Volume	3
Issue number	5
DOIs	https://doi.org/10.4161/onci.28927
State	Published - 2014

Keywords

Glioblastoma
Immunosuppression
Immunotherapy
Metabolism
Tryptophan

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Oncology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.4161/onci.28927

Cite this

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title = "M{\'e}nage {\`a} trois: Sustained therapeutic anti-tumor immunity requires multiple partners in malignant glioma",

abstract = "Glioblastoma is an aggressive primary brain cancer. Given our interest in novel immunotherapies, we have recently shown that inhibiting CTLA-4, PD-L1 and IDO results in a dramatic survival advantage in mice with brain tumors. Our preclinical study supports the rapid translation of this approach into phase I clinical trial.",

keywords = "Glioblastoma, Immunosuppression, Immunotherapy, Metabolism, Tryptophan",

author = "Wainwright, {Derek A.} and Lesniak, {Maciej S.}",

note = "Funding Information: This work was supported by an American Brain Tumor Association Discovery Grant (D.A.W.), as well as NIH grants NIH F32 NS073366 (D.A.W.), NIH K99 NS082381 (D.A.W.), R01 CA138587 (M.S.L.), NIH R01 CA122930 (M.S.L.), NIH U01 NS069997 (M.S.L.).",

year = "2014",

doi = "10.4161/onci.28927",

language = "English (US)",

volume = "3",

journal = "OncoImmunology",

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publisher = "Landes Bioscience",

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TY - JOUR

T1 - Ménage à trois

T2 - Sustained therapeutic anti-tumor immunity requires multiple partners in malignant glioma

AU - Wainwright, Derek A.

AU - Lesniak, Maciej S.

N1 - Funding Information: This work was supported by an American Brain Tumor Association Discovery Grant (D.A.W.), as well as NIH grants NIH F32 NS073366 (D.A.W.), NIH K99 NS082381 (D.A.W.), R01 CA138587 (M.S.L.), NIH R01 CA122930 (M.S.L.), NIH U01 NS069997 (M.S.L.).

PY - 2014

Y1 - 2014

N2 - Glioblastoma is an aggressive primary brain cancer. Given our interest in novel immunotherapies, we have recently shown that inhibiting CTLA-4, PD-L1 and IDO results in a dramatic survival advantage in mice with brain tumors. Our preclinical study supports the rapid translation of this approach into phase I clinical trial.

AB - Glioblastoma is an aggressive primary brain cancer. Given our interest in novel immunotherapies, we have recently shown that inhibiting CTLA-4, PD-L1 and IDO results in a dramatic survival advantage in mice with brain tumors. Our preclinical study supports the rapid translation of this approach into phase I clinical trial.

KW - Glioblastoma

KW - Immunosuppression

KW - Immunotherapy

KW - Metabolism

KW - Tryptophan

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DO - 10.4161/onci.28927

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SN - 2162-4011

VL - 3

JO - OncoImmunology

JF - OncoImmunology

IS - 5

M1 - e28927

ER -

Ménage à trois: Sustained therapeutic anti-tumor immunity requires multiple partners in malignant glioma

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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