M-signal hypothesis - metabolic modulation of membrane functions in rat brain

Chandra Shekhar K Mayanil*, Najma Zaheer Baquer

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


1. 1. Monoamine oxidase (amine: oxygen oxidoreductase [deaminating], EC (MAO) and Na+ K+ ATPase ( Na+ K+-ATPase, Mg2+-dependent ATP phosphohydrolase, EC 3,1,6,3) showed reciprocal relationship in their activity patterns during experimentally perturbed situations in vivo as well as in vitro. 2. 2. M-signal hypothesis Is proposed, which attempts at explaining the regulation of plasma membrane function by the intermediate of metabolic processes in the cell. This metabolic intermediate referred to as M-signal exercise its influence on the plasma membrane Na+ K+ ATPase which is responsible for the uptake process.

Original languageEnglish (US)
Pages (from-to)781-784
Number of pages4
JournalProgress in Neuropsychopharmacology and Biological Psychiatry
Issue number5
StatePublished - 1989


  • catecholamine-derived aldehyde
  • metabolism
  • monoamine oxidase Na K ATPase
  • plasma membrane

ASJC Scopus subject areas

  • Pharmacology
  • Biological Psychiatry


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