Machine learning based automated dynamic quantification of left heart chamber volumes

Akhil Narang, Victor Mor-Avi*, Aldo Prado, Valentina Volpato, David Prater, Gloria Tamborini, Laura Fusini, Mauro Pepi, Neha Goyal, Karima Addetia, Alexandra Gonçalves, Amit R. Patel, Roberto M. Lang

*Corresponding author for this work

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

Aims: Studies have demonstrated the ability of a new automated algorithm for volumetric analysis of 3D echocardiographic (3DE) datasets to provide accurate and reproducible measurements of left ventricular and left atrial (LV, LA) volumes at end-systole and end-diastole. Recently, this methodology was expanded using a machine learning (ML) approach to automatically measure chamber volumes throughout the cardiac cycle, resulting in LV and LA volume-time curves. We aimed to validate ejection and filling parameters obtained from these curves by comparing them to independent well-validated reference techniques. Methods and results: We studied 20 patients referred for cardiac magnetic resonance (CMR) examinations, who underwent 3DE imaging the same day. Volume-time curves were obtained for both LV and LA chambers using the ML algorithm (Philips HeartModel), and independently conventional 3DE volumetric analysis (TomTec), and CMR images (slice-by-slice, frame-by-frame manual tracing). Automatically derived LV and LA volumes and ejection/filling parameters were compared against both reference techniques. Minor manual correction of the automatically detected LV and LA borders was needed in 4/20 and 5/20 cases, respectively. Time required to generate volume-time curves was 35 ± 17 s using ML algorithm, 3.6 ± 0.9 min using conventional 3DE analysis, and 96 ± 14 min using CMR. Volume-time curves obtained by all three techniques were similar in shape and magnitude. In both comparisons, ejection/filling parameters showed no significant inter-technique differences. Bland-Altman analysis confirmed small biases, despite wide limits of agreement. Conclusion: The automated ML algorithm can quickly measure dynamic LV and LA volumes and accurately analyse ejection/filling parameters. Incorporation of this algorithm into the clinical workflow may increase the utilization of 3DE imaging.

Original languageEnglish (US)
Article numberjey137
Pages (from-to)541-549
Number of pages9
JournalEuropean heart journal cardiovascular Imaging
Volume20
Issue number5
DOIs
StatePublished - 2019

Keywords

  • 3D echocardiography
  • automation
  • cardiac chamber quantification
  • machine learning

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

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    Narang, A., Mor-Avi, V., Prado, A., Volpato, V., Prater, D., Tamborini, G., Fusini, L., Pepi, M., Goyal, N., Addetia, K., Gonçalves, A., Patel, A. R., & Lang, R. M. (2019). Machine learning based automated dynamic quantification of left heart chamber volumes. European heart journal cardiovascular Imaging, 20(5), 541-549. [jey137]. https://doi.org/10.1093/ehjci/jey137