Macrolide resistance among pediatric pharyngeal Group A streptococci is high in Canada and increasing in the US

Robert R Tanz*, Stanford T Shulman, Virginia D. Shortridge, Bernard Beall, Emily Cederlund, Jason Rippe, James B. Dale

*Corresponding author for this work

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Macrolide resistance (MR) among Group A streptococci (GAS) has implications for treatment of pharyngeal and invasive infections. In Year 1 (2000-2001) and Year 2 (2001-2002) of our ongoing surveillance of pharyngeal GAS, MR rates in the United States were 4.4% and 4.3%, respectively. We now report MR rates among GAS in the US and Canada and describe national differences in emm types and MR genotypes for 2002-2003 (Year 3), 2003-2004 (Year 4), and 2004-2005 (Year 5). MR rates were higher each year in Canada than in the US but the rates appear to be converging. Resistance rates increased significantly in the US from 3.8% in Year 3 to 8.4% in Year 5. MR genotypes and the most prevalent MR emm types varied significantly between the two neighbor nations.

Original languageEnglish (US)
Pages (from-to)95-98
Number of pages4
JournalInternational Congress Series
Volume1289
DOIs
StatePublished - Apr 1 2006

Fingerprint

Macrolides
Streptococcus
Canada
Pediatrics
Genotype
Infection

Keywords

  • Group A streptococcus
  • Macrolide resistance
  • Pharyngitis

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Tanz, Robert R ; Shulman, Stanford T ; Shortridge, Virginia D. ; Beall, Bernard ; Cederlund, Emily ; Rippe, Jason ; Dale, James B. / Macrolide resistance among pediatric pharyngeal Group A streptococci is high in Canada and increasing in the US. In: International Congress Series. 2006 ; Vol. 1289. pp. 95-98.
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abstract = "Macrolide resistance (MR) among Group A streptococci (GAS) has implications for treatment of pharyngeal and invasive infections. In Year 1 (2000-2001) and Year 2 (2001-2002) of our ongoing surveillance of pharyngeal GAS, MR rates in the United States were 4.4{\%} and 4.3{\%}, respectively. We now report MR rates among GAS in the US and Canada and describe national differences in emm types and MR genotypes for 2002-2003 (Year 3), 2003-2004 (Year 4), and 2004-2005 (Year 5). MR rates were higher each year in Canada than in the US but the rates appear to be converging. Resistance rates increased significantly in the US from 3.8{\%} in Year 3 to 8.4{\%} in Year 5. MR genotypes and the most prevalent MR emm types varied significantly between the two neighbor nations.",
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Macrolide resistance among pediatric pharyngeal Group A streptococci is high in Canada and increasing in the US. / Tanz, Robert R; Shulman, Stanford T; Shortridge, Virginia D.; Beall, Bernard; Cederlund, Emily; Rippe, Jason; Dale, James B.

In: International Congress Series, Vol. 1289, 01.04.2006, p. 95-98.

Research output: Contribution to journalArticle

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AU - Tanz, Robert R

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