TY - JOUR
T1 - Macrolide resistance among pediatric pharyngeal Group A streptococci is high in Canada and increasing in the US
AU - Tanz, Robert R.
AU - Shulman, Stanford T.
AU - Shortridge, Virginia D.
AU - Beall, Bernard
AU - Cederlund, Emily
AU - Rippe, Jason
AU - Dale, James B.
N1 - Funding Information:
This work was funded by the U.S. National Institutes of Health (3RO1-A1010085-42S1), IDBiomedical Corporation, and Children's Memorial Research Center.
PY - 2006/4
Y1 - 2006/4
N2 - Macrolide resistance (MR) among Group A streptococci (GAS) has implications for treatment of pharyngeal and invasive infections. In Year 1 (2000-2001) and Year 2 (2001-2002) of our ongoing surveillance of pharyngeal GAS, MR rates in the United States were 4.4% and 4.3%, respectively. We now report MR rates among GAS in the US and Canada and describe national differences in emm types and MR genotypes for 2002-2003 (Year 3), 2003-2004 (Year 4), and 2004-2005 (Year 5). MR rates were higher each year in Canada than in the US but the rates appear to be converging. Resistance rates increased significantly in the US from 3.8% in Year 3 to 8.4% in Year 5. MR genotypes and the most prevalent MR emm types varied significantly between the two neighbor nations.
AB - Macrolide resistance (MR) among Group A streptococci (GAS) has implications for treatment of pharyngeal and invasive infections. In Year 1 (2000-2001) and Year 2 (2001-2002) of our ongoing surveillance of pharyngeal GAS, MR rates in the United States were 4.4% and 4.3%, respectively. We now report MR rates among GAS in the US and Canada and describe national differences in emm types and MR genotypes for 2002-2003 (Year 3), 2003-2004 (Year 4), and 2004-2005 (Year 5). MR rates were higher each year in Canada than in the US but the rates appear to be converging. Resistance rates increased significantly in the US from 3.8% in Year 3 to 8.4% in Year 5. MR genotypes and the most prevalent MR emm types varied significantly between the two neighbor nations.
KW - Group A streptococcus
KW - Macrolide resistance
KW - Pharyngitis
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U2 - 10.1016/j.ics.2005.09.087
DO - 10.1016/j.ics.2005.09.087
M3 - Article
AN - SCOPUS:33645910214
SN - 0531-5131
VL - 1289
SP - 95
EP - 98
JO - International Congress Series
JF - International Congress Series
ER -