@article{33e056ec2d364783acbdfab1d43a4b88,
title = "Macrophage chemotaxis in anti-tubular basement membrane-induced interstitial nephritis in guinea pigs",
abstract = "Interstitial renal lesions containing T cells and macrophages develop after 14 days in guinea pigs immunized to produce anti-tubular basement membrane-induced interstitial nephritis. We serially examined the renal venous and systemic arterial sera from such animals to determine if chemotactic factors were released across their kidneys. Our findings demonstrated the presence of a macrophage-specific renal chemoattractant with peak detectability on Days 10-14, just subsequent to the deposition of αTBM-Ab, but prior to the development of significant renal injury. We propose that such factors may provide important communication signals in the immunopathogenesis of this form of interstitial injury.",
author = "Kennedy, {Thomas L.} and Martha Merrow and {Michael Phillips}, S. and Michael Norman and Neilson, {Eric G.}",
note = "Funding Information: {\textquoteright} This work was supported in part by Grants AM-07006, AM-30280, and AM-20553 from The National Institutes of Health. 2 Current address: Department of Pediatrics, University of Connecticut Health Center, Farmington, Connecticut. 3 Current address: Department of Pediatrics, Wilmington Medical Center, Wilmington, Delaware. 4 To whom correspondence should be sent at Renal-Electrolyte Section, 860 Gates Pavilion, Hospital of The University of Pennsylvania, 3400 Spruce Street, Philadelphia. Pa. 19104. 5 E.G.N. is the recipient of a Clinician-Scientist Award (80-4111 from the American Heart Association. 6 Abbreviations: RTA, renal tubular antigen; CFA, complete Freunds adjuvant; (rTBM-Ab, anti-tubular basement membranes antibodies; CI, chemotactic index; ZAS. zymosan-activated serum: FITC, fluorescein isothiocyanate.",
year = "1985",
month = jul,
doi = "10.1016/0090-1229(85)90126-6",
language = "English (US)",
volume = "36",
pages = "243--248",
journal = "Clinical Immunology and Immunopathology",
issn = "0090-1229",
publisher = "Academic Press Inc.",
number = "2",
}