Macrophage-derived multinucleated giant cells: Hallmarks of the aging ovary

K. Grace Foley, Michele T. Pritchard, Francesca E. Duncan*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

17 Scopus citations


Inflammaging is a state of chronic, low-grade inflammation associated with aging which contributes to age-related diseases. Recently, an age-associated increase in inflammation has been documented in the mammalian ovary, which is accompanied by a shift in the immune cell profile. In this Point of View article, we consider a unique population of macrophage-derived multinucleated giant cells, found in reproductively old mouse ovaries, as potential markers or functional drivers of inflammation in ovarian aging.

Original languageEnglish (US)
Pages (from-to)V5-V9
Issue number2
StatePublished - Feb 2021

ASJC Scopus subject areas

  • Reproductive Medicine
  • Embryology
  • Endocrinology
  • Obstetrics and Gynecology
  • Cell Biology


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