Macrophage-derived multinucleated giant cells: Hallmarks of the aging ovary

K. Grace Foley; Michele T. Pritchard; Francesca E. Duncan

doi:10.1530/REP-20-0489

Macrophage-derived multinucleated giant cells: Hallmarks of the aging ovary

K. Grace Foley, Michele T. Pritchard, Francesca E. Duncan^*

^*Corresponding author for this work

Obstetrics and Gynecology

Research output: Contribution to journal › Review article › peer-review

17 Scopus citations

Abstract

Inflammaging is a state of chronic, low-grade inflammation associated with aging which contributes to age-related diseases. Recently, an age-associated increase in inflammation has been documented in the mammalian ovary, which is accompanied by a shift in the immune cell profile. In this Point of View article, we consider a unique population of macrophage-derived multinucleated giant cells, found in reproductively old mouse ovaries, as potential markers or functional drivers of inflammation in ovarian aging.

Original language	English (US)
Pages (from-to)	V5-V9
Journal	Reproduction
Volume	161
Issue number	2
DOIs	https://doi.org/10.1530/REP-20-0489
State	Published - Feb 2021

ASJC Scopus subject areas

Reproductive Medicine
Embryology
Endocrinology
Obstetrics and Gynecology
Cell Biology

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10.1530/REP-20-0489

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title = "Macrophage-derived multinucleated giant cells: Hallmarks of the aging ovary",

abstract = "Inflammaging is a state of chronic, low-grade inflammation associated with aging which contributes to age-related diseases. Recently, an age-associated increase in inflammation has been documented in the mammalian ovary, which is accompanied by a shift in the immune cell profile. In this Point of View article, we consider a unique population of macrophage-derived multinucleated giant cells, found in reproductively old mouse ovaries, as potential markers or functional drivers of inflammation in ovarian aging.",

author = "{Grace Foley}, K. and Pritchard, {Michele T.} and Duncan, {Francesca E.}",

note = "Funding Information: This work was supported by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01HD093726 to F E D and M T P and R21HD098498 to F E D). Publisher Copyright: {\textcopyright} 2021 Society for Reproduction and Fertility",

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AU - Grace Foley, K.

AU - Pritchard, Michele T.

AU - Duncan, Francesca E.

N1 - Funding Information: This work was supported by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01HD093726 to F E D and M T P and R21HD098498 to F E D). Publisher Copyright: © 2021 Society for Reproduction and Fertility

PY - 2021/2

Y1 - 2021/2

N2 - Inflammaging is a state of chronic, low-grade inflammation associated with aging which contributes to age-related diseases. Recently, an age-associated increase in inflammation has been documented in the mammalian ovary, which is accompanied by a shift in the immune cell profile. In this Point of View article, we consider a unique population of macrophage-derived multinucleated giant cells, found in reproductively old mouse ovaries, as potential markers or functional drivers of inflammation in ovarian aging.

AB - Inflammaging is a state of chronic, low-grade inflammation associated with aging which contributes to age-related diseases. Recently, an age-associated increase in inflammation has been documented in the mammalian ovary, which is accompanied by a shift in the immune cell profile. In this Point of View article, we consider a unique population of macrophage-derived multinucleated giant cells, found in reproductively old mouse ovaries, as potential markers or functional drivers of inflammation in ovarian aging.

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SP - V5-V9

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Macrophage-derived multinucleated giant cells: Hallmarks of the aging ovary

Abstract

ASJC Scopus subject areas

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