Abstract
Inflammaging is a state of chronic, low-grade inflammation associated with aging which contributes to age-related diseases. Recently, an age-associated increase in inflammation has been documented in the mammalian ovary, which is accompanied by a shift in the immune cell profile. In this Point of View article, we consider a unique population of macrophage-derived multinucleated giant cells, found in reproductively old mouse ovaries, as potential markers or functional drivers of inflammation in ovarian aging.
| Original language | English (US) |
|---|---|
| Pages (from-to) | V5-V9 |
| Journal | Reproduction |
| Volume | 161 |
| Issue number | 2 |
| DOIs | |
| State | Published - Feb 2021 |
Funding
This work was supported by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01HD093726 to F E D and M T P and R21HD098498 to F E D).
ASJC Scopus subject areas
- Endocrinology
- Obstetrics and Gynecology
- Cell Biology
- Reproductive Medicine
- Embryology