Macrophages as a Source and Recipient of Wnt Signals

Elizabeth S. Malsin, Seokjo Kim, Anna P. Lam, Cara J. Gottardi

Research output: Contribution to journalReview articlepeer-review

6 Scopus citations

Abstract

Macrophages are often viewed through the lens of their core functions, but recent transcriptomic studies reveal them to be largely distinct across tissue types. While these differences appear to be shaped by their local environment, the key signals that drive these transcriptional differences remain unclear. Since Wnt signaling plays established roles in cell fate decisions, and tissue patterning during development and tissue repair after injury, we consider evidence that Wnt signals both target and are affected by macrophage functions. We propose that the Wnt gradients present in developing and adult tissues effectively shape macrophage fates and phenotypes. We also highlight evidence that macrophages, through an ability to dispatch Wnt signals, may couple tissue debridement and matrix remodeling with stem cell activation and tissue repair.

Original languageEnglish (US)
Pages (from-to)1813
Number of pages1
JournalFrontiers in immunology
Volume10
DOIs
StatePublished - 2019

Keywords

  • Wnt signaling
  • beta catenin
  • immunity
  • macrophages
  • monocytes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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