Macular sub-layer thinning and association with pulmonary function tests in Amyotrophic Lateral Sclerosis

Joseph M. Simonett, Russell Huang, Nailah Siddique, Sina Farsiu, Teepu Siddique, Nicholas J. Volpe, Amani A. Fawzi*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

30 Scopus citations


Amyotrophic Lateral Sclerosis (ALS) is a complex neurodegenerative disorder that may have anterior visual pathway involvement. In this study, we compare the macular structure of patients with ALS to healthy controls, and examine correlations between macular sub-layer thickness measurements and pulmonary function tests and disease duration. ALS patients underwent optical coherence tomography (OCT) imaging to obtain macular cube scans of the right eye. Macular cube OCT data from age-matched healthy subjects were provided by the OCT reading center. Semi-automated retinal segmentation software was used to quantify macular sub-layers. Pulmonary function tests and time since symptom onset were collected retrospectively from the electronic medical records of ALS patients. Macular retinal nerve fiber layer was significantly thinner in ALS patients compared to healthy controls (P < 0.05). Total macular and other sub-layer thicknesses were not reduced in the ALS cohort. Macular retinal nerve fiber layer thickness positively correlated with forced vital capacity % predicted and forced expiratory volume in 1 second % predicted (P < 0.05). In conclusion, analysis of OCT measurements supports the involvement of the anterior visual pathway in ALS. Subtle structural thinning in the macular retinal nerve fiber layer correlates with pulmonary function tests.

Original languageEnglish (US)
Article number29187
JournalScientific reports
StatePublished - Jul 7 2016

ASJC Scopus subject areas

  • General


Dive into the research topics of 'Macular sub-layer thinning and association with pulmonary function tests in Amyotrophic Lateral Sclerosis'. Together they form a unique fingerprint.

Cite this