Magnetic lipid nanocapsules (MLNCs): Self-assembled lipid-based nanoconstruct for non-invasive theranostic applications

Vikas Nandwana, Abhalaxmi Singh, Marisa M. You, Gefei Zhang, John Higham, Tiffany S. Zheng, Yue Li, Pottumarthi V. Prasad, Vinayak P. Dravid*

*Corresponding author for this work

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

We report magnetic nanostructure-stabilized lipid nanocapsules (MLNCs) that show superior structural stability and theranostic properties compared to conventional lipid-based nanocarriers. As therapeutic nanocarriers, the MLNCs exhibit a therapeutic efficacy that is 16 times greater than that of free drugs due to their high payload capacity and actuated drug release ability. In addition, the magnetic resonance contrast enhancement of the MLNCs is nine times higher than that of a clinically approved T2 MRI contrast agent (ferumoxytol), demonstrating the diagnostic imaging capability of the MLNCs in MRI. The self-assembly method to synthesize the lipid nanocapsules is extended to other types of nanoparticles (gold nanoparticles and quantum dots) to produce lipid nanohybrids with distinct physical properties.

Original languageEnglish (US)
Pages (from-to)1026-1034
Number of pages9
JournalJournal of Materials Chemistry B
Volume6
Issue number7
DOIs
StatePublished - 2018

ASJC Scopus subject areas

  • Chemistry(all)
  • Biomedical Engineering
  • Materials Science(all)

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