Magnetic nanoparticles for ferroptosis cancer therapy with diagnostic imaging

Min Jun Ko, Sunhong Min, Hyunsik Hong, Woojung Yoo, Jinmyoung Joo, Yu Shrike Zhang, Heemin Kang*, Dong Hyun Kim*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

10 Scopus citations


Ferroptosis offers a novel method for overcoming therapeutic resistance of cancers to conventional cancer treatment regimens. Its effective use as a cancer therapy requires a precisely targeted approach, which can be facilitated by using nanoparticles and nanomedicine, and their use to enhance ferroptosis is indeed a growing area of research. While a few review papers have been published on iron-dependent mechanism and inducers of ferroptosis cancer therapy that partly covers ferroptosis nanoparticles, there is a need for a comprehensive review focusing on the design of magnetic nanoparticles that can typically supply iron ions to promote ferroptosis and simultaneously enable targeted ferroptosis cancer nanomedicine. Furthermore, magnetic nanoparticles can locally induce ferroptosis and combinational ferroptosis with diagnostic magnetic resonance imaging (MRI). The use of remotely controllable magnetic nanocarriers can offer highly effective localized image-guided ferroptosis cancer nanomedicine. Here, recent developments in magnetically manipulable nanocarriers for ferroptosis cancer nanomedicine with medical imaging are summarized. This review also highlights the advantages of current state-of-the-art image-guided ferroptosis cancer nanomedicine. Finally, image guided combinational ferroptosis cancer therapy with conventional apoptosis-based therapy that enables synergistic tumor therapy is discussed for clinical translations.

Original languageEnglish (US)
Pages (from-to)66-97
Number of pages32
JournalBioactive Materials
StatePublished - Feb 2024


  • Diagnostic imaging
  • Ferroptosis cancer therapy
  • Magnetic nanoparticles
  • Magnetic resonance imaging
  • Synergistic cancer imaging and therapy

ASJC Scopus subject areas

  • Biotechnology
  • Biomedical Engineering
  • Biomaterials


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