TY - GEN
T1 - Magnetic nanostructure-loaded bicontinuous nanospheres for magnetic resonance imaging and drug delivery
AU - Modak, Mallika
AU - Nandwana, Vikas
AU - Dravid, Vinayak
AU - Scott, Evan
N1 - Publisher Copyright:
© 2019 Omnipress - All rights reserved.
PY - 2019
Y1 - 2019
N2 - Statement of Purpose: Poly(ethylene glycol)-bl-poly(propylene sulfide) (PEG-bl-PPS) (Fig 1a) is a versatile block copolymer system capable of forming nanocarriers of various morphologies such as micelles (MCs), polymersomes (PSs), and most recently bicontinuous nanospheres (BCNs)1,2. These nanocarriers have been used to deliver hydrophobic and hydrophilic therapeutics to different target tissues and cells based on particle morphology1,3. To enhance targeting and drug delivery, encapsulating magnetic nanostructures (MNS) (Fig 1b) into PEG-bl-PPS nanocarriers is of interest4. Loading of MNS would provide responsiveness to both 1) static and 2) alternating magnetic fields, allowing for 1) controlled directional manipulation of nanocarriers and 2) hyperthermia-based treatment and actuated drug release5. MNS have also been well established for diagnostic imaging, as they are potent T2 MRI contrast agents4. Here, we have loaded MNS into three different PEG-bl-PPS morphologies and characterized the resulting effects on MR imaging parameters as a first step in developing a magnetic PEG-bl-PPS construct for drug delivery.
AB - Statement of Purpose: Poly(ethylene glycol)-bl-poly(propylene sulfide) (PEG-bl-PPS) (Fig 1a) is a versatile block copolymer system capable of forming nanocarriers of various morphologies such as micelles (MCs), polymersomes (PSs), and most recently bicontinuous nanospheres (BCNs)1,2. These nanocarriers have been used to deliver hydrophobic and hydrophilic therapeutics to different target tissues and cells based on particle morphology1,3. To enhance targeting and drug delivery, encapsulating magnetic nanostructures (MNS) (Fig 1b) into PEG-bl-PPS nanocarriers is of interest4. Loading of MNS would provide responsiveness to both 1) static and 2) alternating magnetic fields, allowing for 1) controlled directional manipulation of nanocarriers and 2) hyperthermia-based treatment and actuated drug release5. MNS have also been well established for diagnostic imaging, as they are potent T2 MRI contrast agents4. Here, we have loaded MNS into three different PEG-bl-PPS morphologies and characterized the resulting effects on MR imaging parameters as a first step in developing a magnetic PEG-bl-PPS construct for drug delivery.
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M3 - Conference contribution
AN - SCOPUS:85065414550
T3 - Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium
SP - 194
BT - Society for Biomaterials Annual Meeting and Exposition 2019
PB - Society for Biomaterials
T2 - 42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence
Y2 - 3 April 2019 through 6 April 2019
ER -