Magnetic nanostructure-loaded bicontinuous nanospheres for magnetic resonance imaging and drug delivery

Mallika Modak, Vikas Nandwana, Vinayak P Dravid, Evan Alexander Scott

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Statement of Purpose: Poly(ethylene glycol)-bl-poly(propylene sulfide) (PEG-bl-PPS) (Fig 1a) is a versatile block copolymer system capable of forming nanocarriers of various morphologies such as micelles (MCs), polymersomes (PSs), and most recently bicontinuous nanospheres (BCNs)1,2. These nanocarriers have been used to deliver hydrophobic and hydrophilic therapeutics to different target tissues and cells based on particle morphology1,3. To enhance targeting and drug delivery, encapsulating magnetic nanostructures (MNS) (Fig 1b) into PEG-bl-PPS nanocarriers is of interest4. Loading of MNS would provide responsiveness to both 1) static and 2) alternating magnetic fields, allowing for 1) controlled directional manipulation of nanocarriers and 2) hyperthermia-based treatment and actuated drug release5. MNS have also been well established for diagnostic imaging, as they are potent T2 MRI contrast agents4. Here, we have loaded MNS into three different PEG-bl-PPS morphologies and characterized the resulting effects on MR imaging parameters as a first step in developing a magnetic PEG-bl-PPS construct for drug delivery.

Original languageEnglish (US)
Title of host publicationSociety for Biomaterials Annual Meeting and Exposition 2019
Subtitle of host publicationThe Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting
PublisherSociety for Biomaterials
Number of pages1
ISBN (Electronic)9781510883901
StatePublished - Jan 1 2019
Event42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Seattle, United States
Duration: Apr 3 2019Apr 6 2019

Publication series

NameTransactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium
Volume40
ISSN (Print)1526-7547

Conference

Conference42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence
CountryUnited States
CitySeattle
Period4/3/194/6/19

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Biotechnology
  • Biomaterials
  • Materials Chemistry

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