Magnetic nanostructure-loaded bicontinuous nanospheres for magnetic resonance imaging and drug delivery

Mallika Modak, Vikas Nandwana, Vinayak P Dravid, Evan Alexander Scott

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Statement of Purpose: Poly(ethylene glycol)-bl-poly(propylene sulfide) (PEG-bl-PPS) (Fig 1a) is a versatile block copolymer system capable of forming nanocarriers of various morphologies such as micelles (MCs), polymersomes (PSs), and most recently bicontinuous nanospheres (BCNs)1,2. These nanocarriers have been used to deliver hydrophobic and hydrophilic therapeutics to different target tissues and cells based on particle morphology1,3. To enhance targeting and drug delivery, encapsulating magnetic nanostructures (MNS) (Fig 1b) into PEG-bl-PPS nanocarriers is of interest4. Loading of MNS would provide responsiveness to both 1) static and 2) alternating magnetic fields, allowing for 1) controlled directional manipulation of nanocarriers and 2) hyperthermia-based treatment and actuated drug release5. MNS have also been well established for diagnostic imaging, as they are potent T2 MRI contrast agents4. Here, we have loaded MNS into three different PEG-bl-PPS morphologies and characterized the resulting effects on MR imaging parameters as a first step in developing a magnetic PEG-bl-PPS construct for drug delivery.

Original languageEnglish (US)
Title of host publicationSociety for Biomaterials Annual Meeting and Exposition 2019
Subtitle of host publicationThe Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting
PublisherSociety for Biomaterials
Number of pages1
ISBN (Electronic)9781510883901
StatePublished - Jan 1 2019
Event42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Seattle, United States
Duration: Apr 3 2019Apr 6 2019

Publication series

NameTransactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium
Volume40
ISSN (Print)1526-7547

Conference

Conference42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence
CountryUnited States
CitySeattle
Period4/3/194/6/19

Fingerprint

Nanospheres
Ethylene Glycol
Nanostructures
Magnetic resonance
Drug delivery
Polyethylene glycols
Polypropylenes
Magnetic Resonance Imaging
Imaging techniques
Pharmaceutical Preparations
Micelles
Diagnostic Imaging
Magnetic Fields
Drug Delivery Systems
Magnetic resonance imaging
Block copolymers
Fever
Tissue
Magnetic fields
Sulfides

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Biotechnology
  • Biomaterials
  • Materials Chemistry

Cite this

Modak, M., Nandwana, V., Dravid, V. P., & Scott, E. A. (2019). Magnetic nanostructure-loaded bicontinuous nanospheres for magnetic resonance imaging and drug delivery. In Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting (Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium; Vol. 40). Society for Biomaterials.
Modak, Mallika ; Nandwana, Vikas ; Dravid, Vinayak P ; Scott, Evan Alexander. / Magnetic nanostructure-loaded bicontinuous nanospheres for magnetic resonance imaging and drug delivery. Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting. Society for Biomaterials, 2019. (Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium).
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Modak, M, Nandwana, V, Dravid, VP & Scott, EA 2019, Magnetic nanostructure-loaded bicontinuous nanospheres for magnetic resonance imaging and drug delivery. in Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting. Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium, vol. 40, Society for Biomaterials, 42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence, Seattle, United States, 4/3/19.

Magnetic nanostructure-loaded bicontinuous nanospheres for magnetic resonance imaging and drug delivery. / Modak, Mallika; Nandwana, Vikas; Dravid, Vinayak P; Scott, Evan Alexander.

Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting. Society for Biomaterials, 2019. (Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium; Vol. 40).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

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AB - Statement of Purpose: Poly(ethylene glycol)-bl-poly(propylene sulfide) (PEG-bl-PPS) (Fig 1a) is a versatile block copolymer system capable of forming nanocarriers of various morphologies such as micelles (MCs), polymersomes (PSs), and most recently bicontinuous nanospheres (BCNs)1,2. These nanocarriers have been used to deliver hydrophobic and hydrophilic therapeutics to different target tissues and cells based on particle morphology1,3. To enhance targeting and drug delivery, encapsulating magnetic nanostructures (MNS) (Fig 1b) into PEG-bl-PPS nanocarriers is of interest4. Loading of MNS would provide responsiveness to both 1) static and 2) alternating magnetic fields, allowing for 1) controlled directional manipulation of nanocarriers and 2) hyperthermia-based treatment and actuated drug release5. MNS have also been well established for diagnostic imaging, as they are potent T2 MRI contrast agents4. Here, we have loaded MNS into three different PEG-bl-PPS morphologies and characterized the resulting effects on MR imaging parameters as a first step in developing a magnetic PEG-bl-PPS construct for drug delivery.

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T3 - Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium

BT - Society for Biomaterials Annual Meeting and Exposition 2019

PB - Society for Biomaterials

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Modak M, Nandwana V, Dravid VP, Scott EA. Magnetic nanostructure-loaded bicontinuous nanospheres for magnetic resonance imaging and drug delivery. In Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting. Society for Biomaterials. 2019. (Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium).