Magnetic Resonance Imaging of Self-Assembled Biomaterial Scaffolds

Thomas Meade (Inventor), Samuel Stupp (Inventor)

Research output: Patent

Abstract

Peptide Amphiphile Conjugated MRI Contrast Agents NU 2004-090 Inventors Steve Bull Thomas Meade* Samuel Stupp* Short Description Contrast agents for magnetic resonance imaging based on self-assembled peptide amphiphiles for high contrast imaging #healthcare #imaging #MRI Abstract Northwestern University researchers have developed novel contrast agents for MRI imaging that incorporate peptide amphiphiles (PAs). These versatile, biocompatible molecules have been exploited for tissue engineering and drug delivery purposes in the past. Because of their ability to self-assemble in vivo, PAs are also attractive as MRI contrast agents. The relaxivity of the PA-based contrast agents is proportional to the molecular weight of the self-assembled complex, which produces increased contrast in MRI images. In addition, these contrast agents are highly sensitive in vivo, allowing for imaging of various biological processes. Due to their chemical properties, PAs can be easily modified to allow for incorporation of multiple bioactive functions further enhancing their range of applications. PA-based contrast agents are expected to contribute to the field of magnetic resonance imaging, as well as enable future improvements in diagnostic imaging techniques. Applications o MRI in clinical and research settings Advantages o Increased sensitivity and contrast o Established bioactivity and biocompatibility o Customizable Publications Bull SR, Guler MO, Bras RE, Meade TJ, Stupp SI (2005) Self-Assembled Peptide Amphiphile Nanofibers Conjugated to MRI Contrast Agents, Nano Lett. 5: 1-4. IP Status Issued US patent number 8,834,840 Marketing Contact Michael Moore, PhD Invention Manager (p) 847.491.4645 (e) michaelmoore@northwestern.edu
Original languageEnglish
Patent number8834840
StatePublished - Sep 16 2014

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Amphiphiles
Biocompatible Materials
Scaffolds
Contrast Media
Peptides
Magnetic resonance imaging
Imaging techniques
Magnetic resonance
Magnetic Resonance Imaging
Nanofibers
Bioactivity
Drug delivery
Tissue engineering
Chemical properties
Managers
Molecular weight
Molecules

Cite this

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title = "Magnetic Resonance Imaging of Self-Assembled Biomaterial Scaffolds",
abstract = "Peptide Amphiphile Conjugated MRI Contrast Agents NU 2004-090 Inventors Steve Bull Thomas Meade* Samuel Stupp* Short Description Contrast agents for magnetic resonance imaging based on self-assembled peptide amphiphiles for high contrast imaging #healthcare #imaging #MRI Abstract Northwestern University researchers have developed novel contrast agents for MRI imaging that incorporate peptide amphiphiles (PAs). These versatile, biocompatible molecules have been exploited for tissue engineering and drug delivery purposes in the past. Because of their ability to self-assemble in vivo, PAs are also attractive as MRI contrast agents. The relaxivity of the PA-based contrast agents is proportional to the molecular weight of the self-assembled complex, which produces increased contrast in MRI images. In addition, these contrast agents are highly sensitive in vivo, allowing for imaging of various biological processes. Due to their chemical properties, PAs can be easily modified to allow for incorporation of multiple bioactive functions further enhancing their range of applications. PA-based contrast agents are expected to contribute to the field of magnetic resonance imaging, as well as enable future improvements in diagnostic imaging techniques. Applications o MRI in clinical and research settings Advantages o Increased sensitivity and contrast o Established bioactivity and biocompatibility o Customizable Publications Bull SR, Guler MO, Bras RE, Meade TJ, Stupp SI (2005) Self-Assembled Peptide Amphiphile Nanofibers Conjugated to MRI Contrast Agents, Nano Lett. 5: 1-4. IP Status Issued US patent number 8,834,840 Marketing Contact Michael Moore, PhD Invention Manager (p) 847.491.4645 (e) michaelmoore@northwestern.edu",
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