Magnetic resonance spectroscopy imaging of lactate in patients with bipolar disorder

Wen Jang Chu, Melissa P. DelBello, Kelly B. Jarvis, Mathew M. Norris, Mi Jung Kim, Wade Weber, Jing Huei Lee, Stephen M. Strakowski, Caleb M. Adler*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

28 Scopus citations


Although brain lactate levels are typically low and difficult to measure, a few previous investigators have reported that brain lactate levels are elevated in patients with bipolar disorder. The present study investigated the distribution of lactate in bipolar and healthy brains using 2D proton magnetic resonance spectroscopic imaging on a 4-Tesla magnetic resonance imaging system. Ratios of the concentration of lactate to N-acetylaspartate, and of lactate to total creatine, were significantly higher in bipolar than in healthy subjects. Lactate signals were primarily localized to the bipolar subjects' caudate and anterior cingulate cortices, components of the frontal-subcortical circuit, suggesting that affective dysregulation may be related to metabolic abnormalities in this network.

Original languageEnglish (US)
Pages (from-to)230-234
Number of pages5
JournalPsychiatry Research - Neuroimaging
Issue number3
StatePublished - Sep 30 2013


  • Anterior cingulate cortex
  • Caudate
  • Magnetic resonance spectroscopy

ASJC Scopus subject areas

  • Neuroscience (miscellaneous)
  • Radiology Nuclear Medicine and imaging
  • Psychiatry and Mental health


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