Magnetic resonance tissue phase mapping of myocardial motion new insight in age and gender

Daniela Föll*, Bernd Jung, Elfriede Schilli, Felix Staehle, Annette Geibel, Jürgen Hennig, Christoph Bode, Michael Markl

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

84 Scopus citations


Background-An exact understanding of normal age-and gender-matched regional myocardial performance is an essential perquisite for the diagnosis of heart disease. Magnetic resonance phase-contrast imaging (tissue phase mapping) enabling the analysis of segmental, 3-directional myocardial velocities with high temporal resolution (13.8 ms) was used to assess left ventricular motion. Methods and Results-Radial, long-axis, and rotational myocardial velocities were acquired in 58 healthy volunteers (3 age groups, 29 women) in left ventricular basal, midventricular, and apical short-axis locations. For increased age, reduced (P<0.003) and prolonged long-axis and radial velocities (P<0.05) during diastole and reduced long-axis velocities (P<0.001) and apical rotation (P<0.005) during systole were found for both genders. Women demonstrated a reduced systolic twist (P=0.009), apical rotation (P=0.01), and systolic radial velocities (P<0.02) compared with men. Segmental analysis of long-axis motion with aging revealed differences in regional reduction of systolic (lateral 52% versus 30%) and diastolic (lateral 57% versus 41%) velocities in women compared with men. In basal segments, young women demonstrated higher long-axis velocities (+11% during diastole) than men, whereas this difference was reversed in older subjects (same segments,-20%). In addition, increased age resulted in a prolonged time to peak diastolic apical rotation (P<0.04) in women compared with men. Conclusions-Age and gender strongly influence regional myocardial motion. Tissue phase mapping provides a comprehensive quantitative analysis of all myocardial velocities with high temporal and spatial resolution. The knowledge of the detected ageand gender-related differences in myocardial motion is fundamental for further investigations of cardiac disease.

Original languageEnglish (US)
Pages (from-to)54-64
Number of pages11
JournalCirculation: Cardiovascular Imaging
Issue number1
StatePublished - Jan 2010


  • Aging
  • Gender
  • Magnetic resonance imaging
  • Myocardial contraction

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine


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